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Positron-Emission Tomography

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Total-Body PET Kinetic Modeling and Potential Opportunities Using Deep Learning.

PET clinics
The uEXPLORER total-body PET/CT system provides a very high level of detection sensitivity and simultaneous coverage of the entire body for dynamic imaging for quantification of tracer kinetics. This article describes the fundamentals and potential b...

A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET.

European journal of nuclear medicine and molecular imaging
PURPOSE: The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due to Alzheimer's disease (MCI-...

Generation of synthetic PET images of synaptic density and amyloid from F-FDG images using deep learning.

Medical physics
PURPOSE: Positron emission tomography (PET) imaging with various tracers is increasingly used in Alzheimer's disease (AD) studies. However, access to PET scans using new or less-available tracers with sophisticated synthesis and short half-life isoto...

Evaluation of Deep Learning-Based Approaches to Segment Bowel Air Pockets and Generate Pelvic Attenuation Maps from CAIPIRINHA-Accelerated Dixon MR Images.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Attenuation correction remains a challenge in pelvic PET/MRI. In addition to the segmentation/model-based approaches, deep learning methods have shown promise in synthesizing accurate pelvic attenuation maps (μ-maps). However, these methods often mis...

Populational and individual information based PET image denoising using conditional unsupervised learning.

Physics in medicine and biology
Our study aims to improve the signal-to-noise ratio of positron emission tomography (PET) imaging using conditional unsupervised learning. The proposed method does not require low- and high-quality pairs for network training which can be easily appli...

Deep residual-convolutional neural networks for event positioning in a monolithic annular PET scanner.

Physics in medicine and biology
PET scanners based on monolithic pieces of scintillator can potentially produce superior performance characteristics (high spatial resolution and detection sensitivity, for example) compared to conventional PET scanners. Consequently, we initiated de...

Deep-learning-based attenuation correction in dynamic [O]HO studies using PET/MRI in healthy volunteers.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Quantitative [O]HO positron emission tomography (PET) is the accepted reference method for regional cerebral blood flow (rCBF) quantification. To perform reliable quantitative [O]HO-PET studies in PET/MRI scanners, MRI-based attenuation-correction (M...

Rapid high-quality PET Patlak parametric image generation based on direct reconstruction and temporal nonlocal neural network.

NeuroImage
Parametric imaging based on dynamic positron emission tomography (PET) has wide applications in neurology. Compared to indirect methods, direct reconstruction methods, which reconstruct parametric images directly from the raw PET data, have superior ...

Assessment of deep learning-based PET attenuation correction frameworks in the sinogram domain.

Physics in medicine and biology
This study set out to investigate various deep learning frameworks for PET attenuation correction in the sinogram domain. Different models for both time-of-flight (TOF) and non-TOF PET emission data were implemented, including direct estimation of th...