Cardiomyopathies pose a significant risk of morbidity and mortality worldwide, with dilated cardiomyopathy (DCM) recognized as the leading cause of pediatric heart transplantation. Understanding the unique presentation of DCM in the pediatric populat...
International journal of pharmaceutics
Aug 9, 2025
Nanotheranostics has garnered significant interest for its capacity to improve customized healthcare via targeted and efficient treatment alternatives. Nanotheranostics promises an innovative approach to precision medicine by integrating therapeutic ...
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma in which achieving histologically negative margins is paramount to minimizing recurrence. Mohs micrographic surgery (MMS) has transformed margin control in DFSP by...
BACKGROUND: Atherosclerotic cardiovascular disease poses a heavy burden on the population's health and health care costs. Identifying apparently healthy individuals at risk of developing cardiovascular diseases using clinical prediction models raises...
Given the intricate and multifactorial molecular mechanisms underlying cardiac hypertrophy (CH), conventional pharmacological treatments often face significant challenges in achieving disease reversal. This review presents an innovative approach to t...
Alkaline phosphatase (ALP) is a clinically important hydrolase enzyme and a valuable biomarker for hepatobiliary diseases, metabolic bone disorders, and certain malignancies. Raman-based miniaturized sensors, particularly those employing surface-enha...
International journal of pharmaceutics
Aug 5, 2025
Systemic chemotherapy has long served as a cornerstone in the management of various malignancies. However, its inherent lack of specificity often leads to significant adverse effects, prompting the exploration of innovative nanomedicine strategies to...
Neuroscience and biobehavioral reviews
Aug 5, 2025
Substance use disorders (SUD) are chronic, relapsing conditions marked by high variability in treatment response and frequent relapse. This variability arises from complex interactions among behavioral, environmental, and biological factors unique to...
Digital twin (DT) technology is revolutionizing clinical practice by integrating diverse epidemiological data sources to create dynamic, patient-specific simulations. By leveraging data from genomics, proteomics, imaging, sociodemographics, and real-...
The clinical adenoma - carcinoma progression represents a well-established framework for understanding colorectal cancer (CRC) development, although the molecular mechanisms underlying this transition remain only partially understood. Increasing evid...
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