MOTIVATION: Predicting Drug-Drug Interaction (DDI) has become a crucial step in the drug discovery and development process, owing to the rise in the number of drugs co-administered with other drugs. Consequently, the usage of computational methods fo...
Computer methods and programs in biomedicine
Jun 22, 2018
BACKGROUND AND OBJECTIVE: Drug-drug interaction (DDI) is one of the main causes of toxicity and treatment inefficacy. This work focuses on non-communicable diseases (NCDs), the non-transmissible and long-lasting diseases since they are the leading ca...
Neural networks : the official journal of the International Neural Network Society
Jun 15, 2018
A novel sparsity-based stochastic pooling which integrates the advantages of max-pooling, average-pooling and stochastic pooling is introduced. The proposed pooling is designed to balance the advantages and disadvantages of max-pooling and average-po...
Text mining of scientific libraries and social media has already proven itself as a reliable tool for drug repurposing and hypothesis generation. The task of mapping a disease mention to a concept in a controlled vocabulary, typically to the standard...
This paper presents a robust 3D point cloud registration algorithm based on bidirectional Maximum Correntropy Criterion (MCC). Comparing with traditional registration algorithm based on the mean square error (MSE), using the MCC is superior in dealin...
BACKGROUND: Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches a...
International journal of occupational safety and ergonomics : JOSE
May 9, 2018
This study aimed at establishing fault tree analysis (FTA) using expert opinion to compute the probability of an event. To find the probability of the top event (TE), all probabilities of the basic events (BEs) should be available when the FTA is dra...
Statistical methods in medical research
May 2, 2018
Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, these methods can produ...
Computer methods and programs in biomedicine
Apr 28, 2018
BACKGROUND AND OBJECTIVE: In medical examinations doctors use various techniques in order to provide to the patients an accurate analysis of their actual state of health. One of the commonly used methodologies is the x-ray screening. This examination...