AIMC Topic: Randomized Controlled Trials as Topic

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MoveMentor-examining the effectiveness of a machine learning and app-based digital assistant to increase physical activity in adults: protocol for a randomised controlled trial.

Trials Jul 1, 2025
BACKGROUND: Physical inactivity is prevalent, leading to a high burden of disease and large healthcare costs. Thus, there is a need for affordable, effective and scalable interventions. However, interventions that are affordable and scalable are bese...
Exercise Mobile Applications Humans Health Promotion Machine Learning Randomized Controlled Trials as Topic Adult
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Large Language Model-Assisted Risk-of-Bias Assessment in Randomized Controlled Trials Using the Revised Risk-of-Bias Tool: Usability Study.

Journal of medical Internet research Jun 24, 2025
BACKGROUND: The revised Risk-of-Bias tool (RoB2) overcomes the limitations of its predecessor but introduces new implementation challenges. Studies demonstrate low interrater reliability and substantial time requirements for RoB2 implementation. Larg...
Risk Assessment Randomized Controlled Trials as Topic Bias Large Language Models Humans Language Reproducibility of Results
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Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention.

BMJ open Jun 18, 2025
INTRODUCTION: Psychosis, characterised by chronic symptoms often emerging in youth, imposes a substantial burden on individuals and healthcare systems. While early detection and intervention can mitigate this burden, there is limited evidence on the ...
Early Diagnosis Germany Psychotic Disorders Cost-Benefit Analysis Quality-Adjusted Life Years Artificial Intelligence Adolescent Randomized Controlled Trials as Topic Humans
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Research on the evaluation and rehabilitation training system of upper limb motor function for poststroke patients based on artificial intelligence: a study protocol for a randomized controlled trial.

Trials Jun 13, 2025
BACKGROUND: Stroke-induced upper limb dysfunction requires functional assessment and rehabilitation. The intelligent rehabilitation assessment and virtual reality training system for upper limb motor function in stroke can accurately and objectively ...
Female Aged Adult Humans Artificial Intelligence Virtual Reality Time Factors Treatment Outcome Recovery of Function Biomechanical Phenomena Male Middle Aged Stroke Rehabilitation Stroke Motor Activity Randomized Controlled Trials as Topic Upper Extremity Disability Evaluation Single-Blind Method
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Efficacy and safety of first-line CDK4/6 inhibitors plus AI therapy for patients with HR +/HER2- advanced breast cancer: a network meta-analysis.

BMC cancer May 8, 2025
BACKGROUND: CDK4/6 inhibitors plus aromatase inhibitors (AI) significantly improve the therapeutic effect of initial treatment for HR + /HER2- advanced breast cancer. However, there is a lack of head-to-head randomized controlled trials involving the...
Network Meta-Analysis as Topic Progression-Free Survival Antineoplastic Combined Chemotherapy Protocols Receptors, Progesterone Aminopyridines Receptor, ErbB-2 Receptors, Estrogen Humans Cyclin-Dependent Kinase 4 Protein Kinase Inhibitors Purines Aromatase Inhibitors Female Treatment Outcome Cyclin-Dependent Kinase 6 Breast Neoplasms Benzimidazoles Randomized Controlled Trials as Topic
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The effect of social robot interventions on anxiety in children in clinical settings: a systematic review and meta-analysis.

Journal of affective disorders Apr 22, 2025
AIMS: Children in clinical settings are prone to anxiety due to developmental limitations, which hinders treatment progress. This systematic review and meta-analysis aimed to evaluate the efficacy of social robot interventions compared to routine car...
Humans Randomized Controlled Trials as Topic Robotics Anxiety Child, Preschool Child
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Recent advances in therapeutic probiotics: insights from human trials.

Clinical microbiology reviews Apr 22, 2025
SUMMARYRecent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome's role in health and disease. However, comprehensive reviews integrating the di...
Humans Gastrointestinal Microbiome Microbiota Gastrointestinal Diseases Probiotics Randomized Controlled Trials as Topic
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Testing a Machine Learning-Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial.

JMIR research protocols Apr 16, 2025
BACKGROUND: Individuals who are socioeconomically disadvantaged have high smoking rates and face barriers to participating in smoking cessation interventions. Computer-tailored health communication, which is focused on finding the most relevant messa...
Poverty Humans Motivation Machine Learning Middle Aged Smokers Vulnerable Populations Female Randomized Controlled Trials as Topic Smoking Cessation Text Messaging Adult Male
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Using the counterfactual framework to estimate non-intention-to-treat estimands in randomised controlled trials: A methodological scoping review.

Contemporary clinical trials Apr 11, 2025
BACKGROUND: Randomised controlled trials (RCTs) commonly estimate intention-to-treat (ITT) estimands. However, when nonadherence to assigned treatment occurs, ITT estimands reflect the effect of being offered treatment, rather than adhering to it and...
Scoping Review as Topic Humans Data Interpretation, Statistical Intention to Treat Analysis Research Design Randomized Controlled Trials as Topic
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Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial.

BMJ open Apr 2, 2025
INTRODUCTION: Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, Kidney Dise...
Humans Artificial Intelligence Randomized Controlled Trials as Topic Immunologic Factors Glomerulonephritis, Membranous Nephrotic Syndrome France Rituximab Female Male Adult Algorithms Multicenter Studies as Topic Prospective Studies Precision Medicine
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