AIMC Topic: Receptors, CXCR4

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Breast cancer-associated high-order SNP-SNP interaction of CXCL12/CXCR4-related genes by an improved multifactor dimensionality reduction (MDR-ER).

Oncology reports Jul 21, 2016
In association studies, the combined effects of single nucleotide polymorphism (SNP)-SNP interactions and the problem of imbalanced data between cases and controls are frequently ignored. In the present study, we used an improved multifactor dimensio...
Humans Breast Neoplasms Genetic Predisposition to Disease Algorithms Female Receptors, CXCR4 Epistasis, Genetic Multifactor Dimensionality Reduction Polymorphism, Single Nucleotide Models, Genetic Chemokine CXCL12
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Identification of CXCR4 inhibitory activity in natural compounds using cheminformatics-guided machine learning algorithms.

Integrative biology : quantitative biosciences from nano to macro Jan 8, 2025
Neurodegenerative disorders are characterised by progressive damage to neurons that leads to cognitive impairment and motor dysfunction. Current treatment options focus only on symptom management and palliative care, without addressing their root cau...
Drug Discovery Biological Products Machine Learning Algorithms Alzheimer Disease Cheminformatics Parkinson Disease Humans Receptors, CXCR4
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[Naringenin promotes osteogenic differentiation of BMSCs via SDF-1α/CXCR4 signaling axis].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2021
PURPOSE: To explore the influence of naringenin on osteogenic differentiation of bone mesenchymal stem cells(BMSCs), and the role of SDF-1α/CXCR4 signaling axis in the osteogenic differentiation by naringenin.
Bone Marrow Cells Rats Flavanones Chemokine CXCL12 Osteogenesis Animals Cells, Cultured Receptors, CXCR4 RNA, Messenger Cell Differentiation
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[rhPDGF-BB promotes migration of bone marrow stromal stem cells in diabetic rats].

Shanghai kou qiang yi xue = Shanghai journal of stomatology Dec 1, 2018
PURPOSE: To evaluate the effect of different concentrations of rhPDGF-BB on bone marrow stromal stem cells(BMSCs) migration in diabetic rat, and related mechanisms of SDF-1 and its G-protein conjugated receptor regulation, provide a theoretical basis...
Phosphatidylinositol 3-Kinases Mesenchymal Stem Cells Recombinant Proteins Bone Marrow Cells Becaplermin Rats Bone Regeneration Receptors, CXCR4 Humans Rats, Sprague-Dawley Diabetes Mellitus, Experimental Animals
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A systematic approach to prioritize drug targets using machine learning, a molecular descriptor-based classification model, and high-throughput screening of plant derived molecules: a case study in oral cancer.

Molecular bioSystems Dec 1, 2015
Systems-biology inspired identification of drug targets and machine learning-based screening of small molecules which modulate their activity have the potential to revolutionize modern drug discovery by complementing conventional methods. To utilize ...
Protein Interaction Mapping Molecular Conformation Binding Sites Receptors, CXCR4 Models, Molecular Mouth Neoplasms High-Throughput Screening Assays Gene Expression Regulation, Neoplastic Antineoplastic Agents, Phytogenic Computational Biology Cell Line, Tumor ROC Curve Gene Regulatory Networks Protein Binding Machine Learning Drug Discovery Humans
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