AIMC Topic: Receptors, G-Protein-Coupled

Clear Filters Showing 11 to 20 of 80 articles

Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Frontiers in immunology Dec 13, 2024
Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-mediated MC activation. In order to assess the impact of culture conditions on functional MRGPRX2 express...
Mast Cells Animals Receptors, Neuropeptide Cattle Nerve Tissue Proteins Interleukin-9 Receptors, G-Protein-Coupled Humans Cells, Cultured
View on PubMed DOI

The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data.

Asian Pacific journal of cancer prevention : APJCP Dec 1, 2024
BACKGROUND: Glioblastoma (GBM) is the most aggressive cancer in the central nervous system in glial cells. Finding novel biomarkers in GBM offers numerous advantages that can contribute to early detection, personalized treatment, improved patient out...
Humans Prognosis Brain Neoplasms Male Middle Aged Female Survival Rate Biomarkers, Tumor Receptors, G-Protein-Coupled Deep Learning Glioblastoma RNA-Seq Gene Expression Regulation, Neoplastic Gene Expression Profiling Transcriptome
View on PubMed DOI

Key genes and pathways in the molecular landscape of pancreatic ductal adenocarcinoma: A bioinformatics and machine learning study.

Computational biology and chemistry Oct 24, 2024
Pancreatic ductal adenocarcinoma (PDAC) is recognized for its aggressive nature, dismal prognosis, and a notably low five-year survival rate, underscoring the critical need for early detection methods and more effective therapeutic approaches. This r...
Pancreatic Neoplasms Carcinoma, Pancreatic Ductal Cell Cycle Proteins Computational Biology Protein Serine-Threonine Kinases Receptors, G-Protein-Coupled Humans Kinesins Machine Learning CDC2 Protein Kinase Biomarkers, Tumor Protein Interaction Maps
View on PubMed DOI

A computational and machine learning approach to identify GPR40-targeting agonists for neurodegenerative disease treatment.

PloS one Oct 8, 2024
The G protein-coupled receptor 40 (GPR40) is known to exert a significant influence on neurogenesis and neurodevelopment within the central nervous system of both humans and rodents. Research findings indicate that the activation of GPR40 by an agoni...
Receptors, G-Protein-Coupled Humans Ligands Neurodegenerative Diseases Machine Learning Thermodynamics Molecular Dynamics Simulation Molecular Docking Simulation Protein Binding
View on PubMed DOI

A deep learning framework combining molecular image and protein structural representations identifies candidate drugs for pain.

Cell reports methods Sep 27, 2024
Artificial intelligence (AI) and deep learning technologies hold promise for identifying effective drugs for human diseases, including pain. Here, we present an interpretable deep-learning-based ligand image- and receptor's three-dimensional (3D)-str...
Molecular Imaging Pain Ligands Humans Algorithms Drug Discovery Deep Learning Receptors, G-Protein-Coupled
View on PubMed DOI

A Machine Learning Algorithm Suggests Repurposing Opportunities for Targeting Selected GPCRs.

International journal of molecular sciences Sep 23, 2024
Repurposing utilizes existing drugs with known safety profiles and discovers new uses by combining experimental and computational approaches. The integration of computational methods has greatly advanced drug repurposing, offering a rational approach...
Algorithms Drug Discovery Receptors, G-Protein-Coupled Drug Repositioning Ligands Humans Machine Learning
View on PubMed DOI

GPCRSPACE: A New GPCR Real Expanded Library Based on Large Language Models Architecture and Positive Sample Machine Learning Strategies.

Journal of medicinal chemistry Sep 17, 2024
The quest for novel therapeutics targeting G protein-coupled receptors (GPCRs), essential in numerous physiological processes, is crucial in drug discovery. Despite the abundance of GPCR-targeting drugs, many receptors lack selective modulators, indi...
Small Molecule Libraries Machine Learning Drug Discovery Receptors, G-Protein-Coupled Humans
View on PubMed DOI

The path to the G protein-coupled receptor structural landscape: Major milestones and future directions.

British journal of pharmacology Aug 29, 2024
G protein-coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, ph...
Animals Receptors, G-Protein-Coupled Protein Conformation Humans
View on PubMed DOI

VmmScore: An umami peptide prediction and receptor matching program based on a deep learning approach.

Computers in biology and medicine Jun 29, 2024
Peptides, with recognized physiological and medical implications, such as the ability to lower blood pressure and lipid levels, are central to our research on umami taste perception. This study introduces a computational strategy to tackle the challe...
Taste Perception Deep Learning Receptors, G-Protein-Coupled Taste Peptides Software Molecular Docking Simulation Algorithms Animals Humans
View on PubMed DOI

Computational design of soluble and functional membrane protein analogues.

Nature Jun 19, 2024
De novo design of complex protein folds using solely computational means remains a substantial challenge. Here we use a robust deep learning pipeline to design complex folds and soluble analogues of integral membrane proteins. Unique membrane topolog...
Humans Computer-Aided Design Deep Learning Proteome Amino Acid Motifs Membrane Proteins Protein Stability Receptors, G-Protein-Coupled Proof of Concept Study Models, Molecular Protein Folding Solubility
View on PubMed DOI
Popular Topics
Recent Journals