AIMC Topic: Recombinant Fusion Proteins

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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Retrospective Studies Female Humans Biomarkers Tomography, Optical Coherence Vascular Endothelial Growth Factor A Dose-Response Relationship, Drug Visual Acuity Recombinant Fusion Proteins Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Intravitreal Injections Fluorescein Angiography Deep Learning Angiogenesis Inhibitors Treatment Outcome Follow-Up Studies Male Middle Aged Aged Aged, 80 and over
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Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning: A Post Hoc Analysis of a Randomized Clinical Trial.

JAMA ophthalmology Sep 1, 2020
IMPORTANCE: Large amounts of optical coherence tomographic (OCT) data of diabetic macular edema (DME) are acquired, but many morphologic features have yet to be identified and quantified.
Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Recombinant Fusion Proteins Ranibizumab Visual Acuity Macular Edema Vascular Endothelial Growth Factor A Intravitreal Injections Angiogenesis Inhibitors Follow-Up Studies Middle Aged Deep Learning Retrospective Studies Aged Diabetic Retinopathy Female Male Humans Algorithms
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A reference library for assigning protein subcellular localizations by image-based machine learning.

The Journal of cell biology Mar 2, 2020
Confocal micrographs of EGFP fusion proteins localized at key cell organelles in murine and human cells were acquired for use as subcellular localization landmarks. For each of the respective 789,011 and 523,319 optically validated cell images, morph...
Protein Transport Green Fluorescent Proteins Recombinant Fusion Proteins Machine Learning Organelles Secretory Pathway Animals Microscopy, Confocal Pattern Recognition, Automated Epithelial Cells Humans Image Processing, Computer-Assisted Cell Line Reference Standards Mutation Mice
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[Bactericidal Activity of Constructed Recombinant Fusion Protein Pheromonicin-CT].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Nov 1, 2015
OBJECTIVE: To construct engineering peptide pheromonicin-Clostrzaum tretant krn-ui), and to test its bactericidal activity.
Colicins Mice Animals Anti-Bacterial Agents Hybridomas Recombinant Fusion Proteins Peptides Tomography, X-Ray Computed Clostridium tetani
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