AIMC Topic: Receptors, Vascular Endothelial Growth Factor

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Artificial intelligence system for predicting hand-foot skin reaction induced by vascular endothelial growth factor receptor inhibitors.

Scientific reports Mar 21, 2025
Hand-foot skin reaction (HFSR) is a common adverse effect of vascular endothelial growth factor receptor (VEGFR) inhibitors that significantly impacts patients' quality of life. Prevention and management of HFSR require individualized approaches, but...
Female Risk Factors Aged Adult Male Middle Aged Protein Kinase Inhibitors Receptors, Vascular Endothelial Growth Factor Hand-Foot Syndrome Humans Artificial Intelligence
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Utilization of deep learning to quantify fluid volume of neovascular age-related macular degeneration patients based on swept-source OCT imaging: The ONTARIO study.

PloS one Feb 14, 2022
PURPOSE: To evaluate the predictive ability of a deep learning-based algorithm to determine long-term best-corrected distance visual acuity (BCVA) outcomes in neovascular age-related macular degeneration (nARMD) patients using baseline swept-source o...
Adult Deep Learning Visual Acuity Tomography, Optical Coherence Retina Humans Retrospective Studies Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Retinal Detachment Macular Degeneration Intravitreal Injections Proof of Concept Study Recombinant Fusion Proteins
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Quantification of Key Retinal Features in Early and Late Age-Related Macular Degeneration Using Deep Learning.

American journal of ophthalmology Jan 8, 2021
PURPOSE: We sought to develop and validate a deep learning model for segmentation of 13 features associated with neovascular and atrophic age-related macular degeneration (AMD).
Tomography, Optical Coherence Vascular Endothelial Growth Factor A Intravitreal Injections Recombinant Fusion Proteins Ranibizumab Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Retinal Drusen Choroidal Neovascularization Geographic Atrophy Deep Learning ROC Curve Angiogenesis Inhibitors Models, Statistical Humans Visual Acuity Neural Networks, Computer Aged, 80 and over Female Sensitivity and Specificity Aged Male Middle Aged
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Deep phenotype unsupervised machine learning revealed the significance of pachychoroid features in etiology and visual prognosis of age-related macular degeneration.

Scientific reports Oct 28, 2020
Unsupervised machine learning has received increased attention in clinical research because it allows researchers to identify novel and objective viewpoints for diseases with complex clinical characteristics. In this study, we applied a deep phenotyp...
Choroid Macular Degeneration Intravitreal Injections Recombinant Fusion Proteins Receptors, Vascular Endothelial Growth Factor Choroidal Neovascularization Aged Humans Aged, 80 and over Prognosis Male Retrospective Studies Angiogenesis Inhibitors Female Unsupervised Machine Learning
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A semi-automated machine-learning based workflow for ellipsoid zone analysis in eyes with macular edema: SCORE2 pilot study.

PloS one Apr 30, 2020
BACKGROUND AND OBJECTIVE: To develop a semi-automated, machine-learning based workflow to evaluate the ellipsoid zone (EZ) assessed by spectral domain optical coherence tomography (SD-OCT) in eyes with macular edema secondary to central retinal or he...
Middle Aged Pilot Projects Image Processing, Computer-Assisted Recombinant Fusion Proteins Angiogenesis Inhibitors Tomography, Optical Coherence Humans Macula Lutea Machine Learning Treatment Outcome Drug Monitoring Receptors, Vascular Endothelial Growth Factor Female Workflow Bevacizumab Adult Macular Edema Retinal Vein Occlusion Male Vascular Endothelial Growth Factor A
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Changes in systemic vascular endothelial growth factor levels after intravitreal injection of aflibercept in infants with retinopathy of prematurity.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie Dec 30, 2017
BACKGROUND: To investigate the levels of VEGF in the systemic circulation of patients with type 1 ROP who received intravitreal injections of 1 mg (0.025 mL) aflibercept (IVA) or 0.625 mg (0.025 mL) bevacizumab (IVB).
Angiogenesis Inhibitors Intravitreal Injections Treatment Outcome Female Humans Follow-Up Studies Recombinant Fusion Proteins Infant, Newborn Dose-Response Relationship, Drug Prospective Studies Receptors, Vascular Endothelial Growth Factor Male Vascular Endothelial Growth Factors Retinopathy of Prematurity Biomarkers Time Factors Prognosis Enzyme-Linked Immunosorbent Assay
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Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration.

BMJ open ophthalmology Jun 1, 2025
PURPOSE: Age-related macular degeneration (AMD) remains the leading cause of blindness in developed countries. There are many different intravitreal anti-vascular endothelial growth factor (VEGF) drugs available for the treatment of neovascular AMD (...
Male Middle Aged Deep Learning Angiogenesis Inhibitors Treatment Outcome Biomarkers Retrospective Studies Female Aged Aged, 80 and over Intravitreal Injections Fluorescein Angiography Recombinant Fusion Proteins Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor Follow-Up Studies Dose-Response Relationship, Drug Visual Acuity Tomography, Optical Coherence Humans Vascular Endothelial Growth Factor A
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Artificial intelligence-based predictions in neovascular age-related macular degeneration.

Current opinion in ophthalmology Sep 1, 2021
PURPOSE OF REVIEW: Predicting treatment response and optimizing treatment regimen in patients with neovascular age-related macular degeneration (nAMD) remains challenging. Artificial intelligence-based tools have the potential to increase confidence ...
Angiogenesis Inhibitors Tomography, Optical Coherence Vascular Endothelial Growth Factor A Macular Degeneration Neovascularization, Pathologic Humans Artificial Intelligence Computer Simulation Prognosis Fluorescein Angiography Wet Macular Degeneration Receptors, Vascular Endothelial Growth Factor
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Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning: A Post Hoc Analysis of a Randomized Clinical Trial.

JAMA ophthalmology Sep 1, 2020
IMPORTANCE: Large amounts of optical coherence tomographic (OCT) data of diabetic macular edema (DME) are acquired, but many morphologic features have yet to be identified and quantified.
Angiogenesis Inhibitors Follow-Up Studies Visual Acuity Macular Edema Vascular Endothelial Growth Factor A Intravitreal Injections Recombinant Fusion Proteins Ranibizumab Receptors, Vascular Endothelial Growth Factor Subretinal Fluid Female Aged Male Middle Aged Deep Learning Humans Diabetic Retinopathy Algorithms Retrospective Studies
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