BACKGROUND: A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is highly cell-...
Clinical risk stratification for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HC) employs rules derived from American College of Cardiology Foundation/American Heart Association (ACCF/AHA) guidelines or the HCM Risk-SCD model (C-index ∼...
Computational intelligence and neuroscience
Feb 26, 2019
In recent years, convolutional neural network (CNN) has attracted considerable attention since its impressive performance in various applications, such as Arabic sentence classification. However, building a powerful CNN for Arabic sentiment classific...
Journal of chemical information and modeling
Feb 22, 2019
Binding prediction between targets and drug-like compounds through deep neural networks has generated promising results in recent years, outperforming traditional machine learning-based methods. However, the generalization capability of these classif...
Archives of pathology & laboratory medicine
Feb 20, 2019
CONTEXT.—: Turnaround time and productivity of clinical mass spectrometric (MS) testing are hampered by time-consuming manual review of the analytical quality of MS data before release of patient results.
This paper presents a new approach to automatic three-dimensional (3D) cephalometric annotation for diagnosis, surgical planning, and treatment evaluation. There has long been considerable demand for automated cephalometric landmarking, since manual ...
PURPOSE: To investigate and compare the reproducibility and accuracy of qualitative ratings and quantitative texture analysis (TA) in detection and grading of lumbar spinal stenosis (LSS) in magnetic resonance imaging (MR) scans of the lumbar spine.
Journal of cellular and molecular medicine
Feb 19, 2019
Hepatocellular carcinoma (HCC) is closely associated with abnormal DNA methylation. In this study, we analyzed 450K methylation chip data from 377 HCC samples and 50 adjacent normal samples in the TCGA database. We screened 47,099 differentially meth...
IEEE transactions on bio-medical engineering
Feb 18, 2019
The assessment of Parkinson's disease (PD) poses a significant challenge, as it is influenced by various factors that lead to a complex and fluctuating symptom manifestation. Thus, a frequent and objective PD assessment is highly valuable for effecti...
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