Schizophrenia is a persistent and serious mental illness that leads to distortions in cognition, perception, emotions, speech, self-awareness, and actions. Affecting about 1% of people worldwide, schizophrenia usually emerges in late adolescence or e...
BACKGROUND: Predicting outcomes in schizophrenia spectrum disorders is challenging due to the variability of individual trajectories. While machine learning (ML) shows promise in outcome prediction, it has not yet been integrated into clinical practi...
Schizophrenia (SZ) and Bipolar disorder (BD) share genetic and cerebral abnormalities, supporting an expanded continuum hypothesis. In this paper, we aim to better characterize differences and commonalities of gray and white matter features between S...
Approaches studying the dynamics of resting-state functional magnetic resonance imaging (rs-fMRI) activity often focus on time-resolved functional connectivity (tr-FC). While many tr-FC approaches have been proposed, most are linear approaches, e.g. ...
Motor activity alterations are key symptoms of psychiatric disorders like schizophrenia. Actigraphy, a non-invasive monitoring method, shows promise in early identification. This study characterizes Positive Schizotypy Factor (PSF) and Chronic Schizo...
. Functional network connectivity (FNC) estimated from resting-state functional magnetic resonance imaging showed great information about the neural mechanism in different brain disorders. But previous research has mainly focused on standard statisti...
BACKGROUND: Accurate genetic risk prediction and understanding the mechanisms underlying complex diseases are essential for effective intervention and precision medicine. However, current methods often struggle to capture the intricate and subtle gen...
The study of biological age prediction using various biological data has been widely explored. However, single biological data may offer limited insights into the pathological process of aging and diseases. Here we evaluated the performance of machin...
Social interactions are essential for the survival of individuals and the reproduction of populations. Social stressors, such as social defeat and isolation, can lead to emotional disorders and cognitive impairments. Furthermore, dysfunctional social...
BACKGROUND: Cortical morphological abnormalities in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) have been identified in past research. However, their potential as objective biomarkers to differentiate these disorde...
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