AIMC Topic: Sequence Analysis, DNA
Clear Filters Showing 81 to 90 of 269 articles
Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning.
Nature biomedical engineering
Jun 15, 2021
The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the analysis of ctDNA biomarkers for the detection or monitoring of early-stage cancers challenging. Here we show that deep methylation sequencing aided by a machine-learning...
Using deep learning to identify recent positive selection in malaria parasite sequence data.
Malaria journal
Jun 14, 2021
BACKGROUND: Malaria, caused by Plasmodium parasites, is a major global public health problem. To assist an understanding of malaria pathogenesis, including drug resistance, there is a need for the timely detection of underlying genetic mutations and ...
DNAscent v2: detecting replication forks in nanopore sequencing data with deep learning.
BMC genomics
Jun 9, 2021
BACKGROUND: Measuring DNA replication dynamics with high throughput and single-molecule resolution is critical for understanding both the basic biology behind how cells replicate their DNA and how DNA replication can be used as a therapeutic target f...
MetaVelvet-DL: a MetaVelvet deep learning extension for de novo metagenome assembly.
BMC bioinformatics
Jun 2, 2021
BACKGROUND: The increasing use of whole metagenome sequencing has spurred the need to improve de novo assemblers to facilitate the discovery of unknown species and the analysis of their genomic functions. MetaVelvet-SL is a short-read de novo metagen...
Feasibility of predicting allele specific expression from DNA sequencing using machine learning.
Scientific reports
May 19, 2021
Allele specific expression (ASE) concerns divergent expression quantity of alternative alleles and is measured by RNA sequencing. Multiple studies show that ASE plays a role in hereditary diseases by modulating penetrance or phenotype severity. Howev...
An approach using ddRADseq and machine learning for understanding speciation in Antarctic Antarctophilinidae gastropods.
Scientific reports
Apr 19, 2021
Sampling impediments and paucity of suitable material for molecular analyses have precluded the study of speciation and radiation of deep-sea species in Antarctica. We analyzed barcodes together with genome-wide single nucleotide polymorphisms obtain...
Improving protein domain classification for third-generation sequencing reads using deep learning.
BMC genomics
Apr 9, 2021
BACKGROUND: With the development of third-generation sequencing (TGS) technologies, people are able to obtain DNA sequences with lengths from 10s to 100s of kb. These long reads allow protein domain annotation without assembly, thus can produce impor...
SeqEnhDL: sequence-based classification of cell type-specific enhancers using deep learning models.
BMC research notes
Mar 19, 2021
OBJECTIVE: To address the challenge of computational identification of cell type-specific regulatory elements on a genome-wide scale.
Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning.
Nature communications
Mar 8, 2021
Elucidating functionality in non-coding regions is a key challenge in human genomics. It has been shown that intolerance to variation of coding and proximal non-coding sequence is a strong predictor of human disease relevance. Here, we integrate into...
DeepCAPE: A Deep Convolutional Neural Network for the Accurate Prediction of Enhancers.
Genomics, proteomics & bioinformatics
Feb 11, 2021
The establishment of a landscape of enhancers across human cells is crucial to deciphering the mechanism of gene regulation, cell differentiation, and disease development. High-throughput experimental approaches, which contain successfully reported e...
Stay Ahead of Medical AI
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.
Subscribe NowPopular Topics
- Machine Learning 30978
- Neural Networks, Computer 29696
- Algorithms 26813
- Deep Learning 26324
- Artificial Intelligence 24267
- Robotics 13307
- Image Processing, Computer-Assisted 9512
- Retrospective Studies 9097
- Magnetic Resonance Imaging 6173
- Reproducibility of Results 5589
- Tomography, X-Ray Computed 4765
- Support Vector Machine 4678
- Computational Biology 4229
- Brain 4045
- Computer Simulation 3877
Recent Journals
- Scientific reports 5865
- Sensors (Basel, Switzerland) 4794
- PloS one 4011
- Neural networks : the official journal of the International Neural Network Society 2928
- Computational intelligence and neuroscience 1931
- Computers in biology and medicine 1839
- Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 1686
- Studies in health technology and informatics 1278
- IEEE journal of biomedical and health informatics 1129
- Journal of chemical information and modeling 994
- Nature communications 938
- Computer methods and programs in biomedicine 883
- Bioinformatics (Oxford, England) 861
- Briefings in bioinformatics 850
- IEEE transactions on neural networks and learning systems 823