In the optimization of deep neural networks (DNNs) via evolutionary algorithms (EAs) and the implementation of the training necessary for the creation of the objective function, there is often a trade-off between efficiency and flexibility. Pure soft...
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called ...
IEEE/ACM transactions on computational biology and bioinformatics
Apr 26, 2018
Control of gene regulatory networks (GRNs) to shift gene expression from undesirable states to desirable ones has received much attention in recent years. Most of the existing methods assume that the cost of intervention at each state and time point,...
Computational drug repositioning has been proven as a promising and efficient strategy for discovering new uses from existing drugs. To achieve this goal, a number of computational methods have been proposed, which are based on different data sources...
Unlike daily routine images, ultrasound images are usually monochrome and low-resolution. In ultrasound images, the cancer regions are usually blurred, vague margin and irregular in shape. Moreover, the features of cancer region are very similar to n...
BACKGROUND: Recent cancer genome studies on many human cancer types have relied on multiple molecular high-throughput technologies. Given the vast amount of data that has been generated, there are surprisingly few databases which facilitate access to...
Hybridization and gene flow between species appears to be common. Even though it is clear that hybridization is widespread across all surveyed taxonomic groups, the magnitude and consequences of introgression are still largely unknown. Thus it is cru...
Transposable elements (TEs) are repetitive nucleotide sequences that make up a large portion of eukaryotic genomes. They can move and duplicate within a genome, increasing genome size and contributing to genetic diversity within and across species. A...
Journal of computational biology : a journal of computational molecular cell biology
Apr 18, 2018
Accurate splice-site prediction is essential to delineate gene structures from sequence data. Several computational techniques have been applied to create a system to predict canonical splice sites. For classification tasks, deep neural networks (DNN...
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