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Spectrum Analysis, Raman

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Surface-functionalized SERS platform for deep learning-assisted diagnosis of Alzheimer's disease.

Biosensors & bioelectronics
Early diagnosis of Alzheimer's disease is crucial to stall the deterioration of brain function, but conventional diagnostic methods require complicated analytical procedures or inflict acute pain on the patient. Then, label-free Surface-enhanced Rama...

Fast Real-Time Brain Tumor Detection Based on Stimulated Raman Histology and Self-Supervised Deep Learning Model.

Journal of imaging informatics in medicine
In intraoperative brain cancer procedures, real-time diagnosis is essential for ensuring safe and effective care. The prevailing workflow, which relies on histological staining with hematoxylin and eosin (H&E) for tissue processing, is resource-inten...

Rapid and accurate identification of marine bacteria spores at a single-cell resolution by laser tweezers Raman spectroscopy and deep learning.

Journal of biophotonics
Marine bacteria have been considered as important participants in revealing various carbon/sulfur/nitrogen cycles of marine ecosystem. Thus, how to accurately identify rare marine bacteria without a culture process is significant and valuable. In thi...

Deep Learning Enabled SERS Identification of Gaseous Molecules on Flexible Plasmonic MOF Nanowire Films.

ACS sensors
Through the capture of a target molecule at the metal surface with a highly confined electromagnetic field induced by surface plasmon, surface enhanced Raman spectroscopy (SERS) emerges as a spectral analysis technology with high sensitivity. However...

Determination of Trace Organic Contaminant Concentration via Machine Classification of Surface-Enhanced Raman Spectra.

Environmental science & technology
Surface-enhanced Raman spectroscopy (SERS) has been well explored as a highly effective characterization technique that is capable of chemical pollutant detection and identification at very low concentrations. Machine learning has been previously use...

Point-of-care diagnosis of tissue fibrosis: a review of advances in vibrational spectroscopy with machine learning.

Pathology
Histopathology is the gold standard for diagnosing fibrosis, but its routine use is constrained by the need for additional stains, time, personnel and resources. Vibrational spectroscopy is a novel technique that offers an alternative atraumatic appr...

Nanoisland SERS-Substrates for Specific Detection and Quantification of Influenza A Virus.

Biosensors
Surface-enhanced Raman spectroscopy (SERS)-based aptasensors for virus determination have attracted a lot of interest recently. This approach provides both specificity due to an aptamer component and a low limit of detection due to signal enhancement...

Guided principal component analysis (GPCA): a simple method for improving detection of a known analyte.

The Analyst
There is increasing interest in the application of Raman spectroscopy in a medical setting, ranging from supporting real-time clinical decisions surgical margins to assisting pathologists with disease classification. However, there remain a number o...

Multi-scale representation of surface-enhanced Raman spectroscopy data for deep learning-based liver cancer detection.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
The early detection of liver cancer greatly improves survival rates and allows for less invasive treatment options. As a non-invasive optical detection technique, Surface-Enhanced Raman Spectroscopy (SERS) has shown significant potential in early can...

Rapid visualization of PD-L1 expression level in glioblastoma immune microenvironment via machine learning cascade-based Raman histopathology.

Journal of advanced research
INTRODUCTION: Combination immunotherapy holds promise for improving survival in responsive glioblastoma (GBM) patients. Programmed death-ligand 1 (PD-L1) expression in immune microenvironment (IME) is the most important predictive biomarker for immun...