AIMC Topic: Staphylococcus aureus
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Deep Learning-Assisted Surface-Enhanced Raman Scattering for Rapid Bacterial Identification.
ACS applied materials & interfaces
May 22, 2023
Bloodstream infection (BSI) is characterized by the presence of viable microorganisms in the bloodstream and may induce systemic immune responses. Early and appropriate antibiotic usage is crucial to effectively treating BSI. However, conventional cu...
Nitric oxide releasing polyvinyl alcohol and sodium alginate hydrogels as antibacterial and conductive strain sensors.
International journal of biological macromolecules
Apr 23, 2023
Conductive hydrogels have promising applications in flexible electronic devices and artificial intelligence, which have attracted much attention in recent years. However, most conductive hydrogels have no antimicrobial activity, inevitably leading to...
S. aureus and IgE-mediated diseases: pilot or copilot? A narrative review.
Expert review of clinical immunology
May 9, 2022
INTRODUCTION: is a major opportunistic pathogen that has been implicated in the pathogenesis of several chronic inflammatory diseases including bronchial asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), chronic spontaneous urticaria (CSU),...
Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning.
Nature medicine
Jan 10, 2022
Early use of effective antimicrobial treatments is critical for the outcome of infections and the prevention of treatment resistance. Antimicrobial resistance testing enables the selection of optimal antibiotic treatments, but current culture-based t...
The Microorganism Detection System (SDM) for microbiological control of cosmetic products.
Annals of agricultural and environmental medicine : AAEM
Dec 16, 2021
The Microorganism Detection System (SDM) is a new solution using artificial intelligence, unique on the international scale, to correctly identify and count microorganisms, with particular emphasis on specificlisted microorganisms (Document of Standa...
Main-Chain Sulfonium-Containing Homopolymers with Negligible Hemolytic Toxicity for Eradication of Bacterial and Fungal Biofilms.
ACS macro letters
Dec 10, 2021
Antimicrobials against planktonic cells and established biofilms at low doses are in increasing demand to tackle antibiotic-resistant biofilm infections. As a promising alternative to antibiotics, cationic polymers can effectively kill planktonic mic...
Fast identification of off-target liabilities in early antibiotic discovery with Fourier-transform infrared spectroscopy.
Biotechnology and bioengineering
Aug 20, 2021
Structural modifications of known antibiotic scaffolds have kept the upper hand on resistance, but we are on the verge of not having antibiotics for many common infections. Mechanism-based discovery assays reveal novelty, exclude off-target liabiliti...
Decreased neutrophil-mediated bacterial killing in COVID-19 patients.
Scandinavian journal of immunology
Jun 11, 2021
The coronavirus disease COVID-19 was first described in December 2019. The peripheral blood of COVID-19 patients have increased numbers of neutrophils which are important in controlling the bacterial infections observed in COVID-19. We sought to eval...
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations.
Nature biomedical engineering
Mar 11, 2021
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report an efficient computational method for the generation of antimicrob...
Female
Animals
Drug Design
Drug Discovery
Deep Learning
Microbial Sensitivity Tests
Antimicrobial Cationic Peptides
Anti-Bacterial Agents
Structure-Activity Relationship
Drug Resistance, Bacterial
Molecular Dynamics Simulation
Escherichia coli
Staphylococcus aureus
Mice, Inbred BALB C
Mice
Klebsiella pneumoniae
Klebsiella Infections
Amino Acid Sequence
Pseudomonas aeruginosa
Acinetobacter baumannii
Antibiofilm Activity of α-Amylase from Bacillus subtilis and Prediction of the Optimized Conditions for Biofilm Removal by Response Surface Methodology (RSM) and Artificial Neural Network (ANN).
Applied biochemistry and biotechnology
Mar 1, 2021
α-amylase is known to have antibiofilm activity against biofilms of both Gram positive and Gram-negative bacterial strains. Partially purified α-amylase from Bacillus subtilis was found to have inhibit biofilm formed by P. aeruginosa and S. aureus. T...
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