AIMC Topic: Sulfonamides

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Inhibition of choline kinase as an antiamoebic approach in Entamoeba histolytica infection.

Tropical biomedicine Dec 1, 2023
Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic colitis or amoebic liver abscess. Metronidazole has been the conventional treatment for intestinal amoebiasis, but concerns regarding resistance have emerge...
Sulfonamides Humans Entamoebiasis RNA, Small Interfering Metronidazole Amebiasis Isoquinolines Choline Kinase Entamoeba histolytica
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[A real-world study of paritaprevir/ritonavir-ombitasvir combined with dasabuvir in the treatment of genotype 1b chronic hepatitis C].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec 20, 2018
To recognize the efficacy and safety of paritaprevir/ritonavir-ombitasvir combined with dasabuvir (OBV/PTV/RTV+DSV) in the treatment of genotype 1b chronic hepatitis C. Patients with genotype 1b chronic hepatitis C who were admitted to the People's...
Ritonavir Drug Therapy, Combination Hepatitis C, Chronic Valine Hepacivirus Male Lactams, Macrocyclic Ribavirin Proline Middle Aged Macrocyclic Compounds 2-Naphthylamine Cyclopropanes Humans Anilides Uracil Sulfonamides Carbamates China Antiviral Agents Genotype Treatment Outcome
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PHARMACOKINETICS AND BIOEQUIVALENCE STUDIES OF TWO NIMESULIDE 100 mg TABLETS: UNIT DOSE, RANDOMIZED-SEQUENCE, TWO-WAY CROSSOVER STUDY IN HEALTHY VOLUNTEERS OF PAKISTANI POPULATION.

Acta poloniae pharmaceutica Mar 1, 2017
Single centered crossover, two cycles volunteer study was performed on 12 healthy male volunteers. Both reference and test, immediate release nimesulide formulation was given in a randomized manner with a washout period of 15 days and 5 mL of blood s...
Cross-Over Studies Healthy Volunteers Pakistan Administration, Oral Therapeutic Equivalency Half-Life Metabolic Clearance Rate Models, Biological Sulfonamides Tablets Chromatography, High Pressure Liquid Anti-Inflammatory Agents, Non-Steroidal Area Under Curve Young Adult Humans Male
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[Simultaneous determination of sivelestat and its metabolite XW-IMP-A in human plasma using HPLC-MS/MS].

Yao xue xue bao = Acta pharmaceutica Sinica Oct 1, 2015
A simple and rapid method was developed based on high performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) to determine sivelestat and its metabolite XW-IMP-A in human plasma. After a simple protein precipitation, the samp...
Humans Chromatography, High Pressure Liquid Tandem Mass Spectrometry Inosine Monophosphate Sulfonamides Glycine Reproducibility of Results Chromatography, Liquid
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Compressed images for affinity prediction-2 (CIFAP-2): an improved machine learning methodology on protein-ligand interactions based on a study on caspase 3 inhibitors.

Journal of enzyme inhibition and medicinal chemistry Jan 1, 2015
The aim of this study is to propose an improved computational methodology, which is called Compressed Images for Affinity Prediction-2 (CIFAP-2) to predict binding affinities of structurally related protein-ligand complexes. CIFAP-2 method is establi...
Caspase 3 Regression Analysis Machine Learning Dose-Response Relationship, Drug Sulfonamides Ligands Enzyme Inhibitors Structure-Activity Relationship Molecular Structure Humans
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