New methods and algorithms are being developed for predicting untested phenotypes in schemes commonly used in genomic selection (GS). The prediction of disease resistance in GS has its own peculiarities: a) there is consensus about the additive natur...
MOTIVATION: Identifying molecular mechanisms that drive cancers from early to late stages is highly important to develop new preventive and therapeutic strategies. Standard machine learning algorithms could be used to discriminate early- and late-sta...
MOTIVATION: Many inference problems in bioinformatics, including drug bioactivity prediction, can be formulated as pairwise learning problems, in which one is interested in making predictions for pairs of objects, e.g. drugs and their targets. Kernel...
Journal of the American Medical Informatics Association : JAMIA
Jul 1, 2018
OBJECTIVE: To automatically recognize self-acknowledged limitations in clinical research publications to support efforts in improving research transparency.
MOTIVATION: Protein O-GlcNAcylation (O-GlcNAc) is an important post-translational modification of serine (S)/threonine (T) residues that involves multiple molecular and cellular processes. Recent studies have suggested that abnormal O-G1cNAcylation c...
MOTIVATION: Protein-protein interactions (PPI) play a crucial role in our understanding of protein function and biological processes. The standardization and recording of experimental findings is increasingly stored in ontologies, with the Gene Ontol...
MOTIVATION: Molecular subtypes of cancers and autoimmune disease, defined by transcriptomic profiling, have provided insight into disease pathogenesis, molecular heterogeneity and therapeutic responses. However, technical biases inherent to different...
Water science and technology : a journal of the International Association on Water Pollution Research
May 1, 2018
This work presents a methodology for automatic detection of structural faults in sewers from CCTV footage, which has been improved by combining the outputs of different machine learning techniques. The predictions of support vector machine and random...
IEEE journal of biomedical and health informatics
May 1, 2018
In this paper, the automatic detection of neovascularization in the optic disc region (NVD) for color fundus retinal image is presented. NV is the indicator for the onset of proliferative diabetic retinopathy and it is featured by the presence of new...
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