Latest AI and machine learning research in genetics for healthcare professionals.
Cardio-oncology patients may face complex treatment regimens due to the concurrent existence of cancer and cardiovascular disease, leading to a considerable polypharmacy burden. This significantly increases the prospect of drug-drug interactions (DDIs) and gene-drug interactions. The majority of these interactions arise from comparable pharmacokinetic and pharmacological pathways associated with d...
Prime editing (PE) can make specific local changes to genomic DNA in living systems but its efficient application currently requires extensive optimization of PE guide RNA (pegRNA) sequences. Here we present OptiPrime, a machine learning model of PE efficiency based on current understanding of PE mechanisms. OptiPrime achieves state-of-the-art accuracy on PE efficiency prediction and enables predi...
Perioperative nivolumab significantly improved event-free survival (EFS) compared with placebo in patients with resectable non-small cell lung cancer ...
Klebsiella pneumoniae (KP) has emerged as a formidable nosocomial pathogen in the era of antimicrobial resistance, with mortality from pneumonia cause...
The ability of organisms to adapt and survive depends on the effects of genes and the environment on fitness. However, the multigenic nature of fitnes...
Morphological switching in response to environmental stimuli is a well-known phenomenon in fungi, leading to diverse morphotypes. Microscopic observat...
MOTIVATION: Genome stability is shaped by DNA sequence and chromatin context, but their relative contributions to double-strand break (DSB) sensitivit...
Nanozyme sensor arrays have garnered significant attention in the sensing field, whereas their practical application remains limited due to the issues...
BACKGROUND: Hypermobile Ehlers-Danlos syndrome (hEDS) is a multisystemic hereditary connective tissue disorder characterized by generalized joint hype...
Effective and sustainable management of coastal ecosystems relies on accurate water quality monitoring and forecasting, particularly in regions facing...
Clonal hematopoiesis of undetermined potential (CHIP), initially discovered as a mere hematological curiosity, now represents a clinically significant...
BACKGROUND: Sepsis is a life-threatening organ dysfunction arising from a dysregulated host response to infection. Cell-cycle disturbance is increasin...
Multidisciplinary genomic evaluation is increasingly recognized for its diagnostic and therapeutic implications in adults with suspected inborn errors...
Innovation arises from exploring unknown areas of knowledge. In most instances, progress occurs incrementally, slowly expanding the boundary of what i...
β-thalassemia comprises a clinically heterogeneous group of disorders in which anemia severity, transfusion exposure, iron loading, and organ complica...
Esophageal cancer is biologically heterogeneous, and conventional clinicopathological staging incompletely captures variation in patient outcomes. Thi...
BACKGROUND: The inability to predict risk in early pregnancy for preeclampsia represents a major limitation in prenatal care. OBJECTIVES: We used mach...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by multifactorial pathology, including amyloid-β (Aβ) aggregation, ...
Designing protein sequences with favorable predicted energetic properties is an important challenge in protein inverse folding, because many existing ...
The Human Genome Project (HGP) was a large international research effort that timelined between 1990 and 2003, marking the successful mapping of the e...