Clinical pharmacology and therapeutics
Oct 6, 2023
Recent breakthroughs in artificial intelligence (AI) and machine learning (ML) have ushered in a new era of possibilities across various scientific domains. One area where these advancements hold significant promise is model-informed drug discovery a...
Clinical pharmacology and therapeutics
Sep 29, 2023
The application of machine learning (ML) has shown promising results in precision medicine due to its exceptional performance in dealing with complex multidimensional data. However, using ML for individualized dosing of medicines is still in its earl...
Clinical pharmacology and therapeutics
Aug 24, 2023
Regulators are faced with many challenges surrounding health data usage, including privacy, fragmentation, validity, and generalizability, especially in the European Union, for which synthetic data may provide innovative solutions. Synthetic data, de...
Clinical pharmacology and therapeutics
Mar 25, 2022
We compared the predictive performance of an artificial neural network to traditional pharmacometric modeling for population prediction of plasma concentrations of valproate in real-world data. We included individuals aged 65 years or older with epil...
Clinical pharmacology and therapeutics
May 8, 2021
Adverse drug reaction (ADR) reporting is a major component of drug safety monitoring; its input will, however, only be optimized if systems can manage to deal with its tremendous flow of information, based primarily on unstructured text fields. The a...
Clinical pharmacology and therapeutics
Apr 19, 2021
Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for ...
Clinical pharmacology and therapeutics
Apr 6, 2021
Therapeutic drug monitoring of mycophenolic acid (MPA) based on area under the curve (AUC) is well-established and machine learning (ML) approaches could help to estimate AUC. The aim of this work is to estimate the AUC of MPA in organ transplant pat...
Clinical pharmacology and therapeutics
Jan 18, 2021
The aim of this work is to estimate the area-under the blood concentration curve of tacrolimus (TAC) following b.i.d. or q.d. dosing in organ transplant patients, using Xgboost machine learning (ML) models. A total of 4,997 and 1,452 TAC interdose ar...
Clinical pharmacology and therapeutics
Oct 24, 2020
Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Know...