Communications biology
Jun 5, 2025
Non-linear interactions among single nucleotide polymorphisms (SNPs), genes, and pathways play an important role in human diseases, but identifying these interactions is a challenging task. Neural networks are state-of-the-art predictors in many doma...
Communications biology
May 25, 2025
Cryogenic electron microscopy (CryoEM) produces structures of macromolecules at near-atomic resolution. However, building molecular models with good stereochemical geometry from those structures can be challenging and time-consuming, especially when ...
Communications biology
May 21, 2025
In principle, ML/AI-based algorithms should enable rapid and accurate cell segmentation in high-throughput settings. However, reliance on large training datasets, human input, computational expertise, and limited generalizability has prevented this g...
Communications biology
May 13, 2025
Current methods for producing cardiomyocytes from human induced pluripotent stem cells (hiPSCs) using 2D monolayer differentiation are often hampered by batch-to-batch variability and inefficient purification processes. Here, we introduce CM-AI, a no...
Communications biology
May 10, 2025
Global patterns of intraspecific genetic diversity are key to understanding evolutionary and ecological processes. However, insights into the distribution and drivers of genetic diversity remain limited, particularly for marine species. Here, we expl...
Communications biology
Apr 18, 2025
Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the tit...
Communications biology
Apr 14, 2025
We had previously reported a convolutional neural network (CNN) based approach, called the holistic kinetic model (HK model 1), for detecting 5-methylcytosine (5mC) by single molecule real-time sequencing (Pacific Biosciences). In this study, we cons...
Communications biology
Apr 11, 2025
Exploring natural or pharmacologically induced brain dynamics, such as sleep, wakefulness, or anesthesia, provides rich functional models for studying brain states. These models allow detailed examination of unique spatiotemporal neural activity patt...
Communications biology
Apr 5, 2025
Identifying DNA-binding proteins and their binding residues is critical for understanding diverse biological processes, but conventional experimental approaches are slow and costly. Existing machine learning methods, while faster, often lack accuracy...
Communications biology
Apr 2, 2025
The microbial rare biosphere, composed of low-abundance microorganisms in a community, lacks a standardized delineation method for its definition. Currently, most studies rely on arbitrary thresholds to define the microbial rare biosphere (e.g., 0.1%...