Journal of nuclear medicine : official publication, Society of Nuclear Medicine
May 8, 2025
The study of the human phenome is essential for understanding the complexities of wellness and disease and their transitions, with molecular imaging being a vital tool in this exploration. Molecular imaging embodies the 4 principles of human phenomic...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
May 1, 2025
Single-time-point (STP) image-based dosimetry offers a more convenient approach for clinical practice in radiopharmaceutical therapy (RPT) compared with conventional multiple-time-point image-based dosimetry. Despite numerous advancements, current ST...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
May 1, 2025
This study investigated the added value of using maximum-intensity projection (MIP) images for fully automatic segmentation of lesions using deep learning (DL) in [F]FDG and [Ga]Ga-prostate-specific membrane antigen (PSMA) PET/CT scans. We used 489 ...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Apr 1, 2025
We previously demonstrated that a deep learning (DL) model of myocardial perfusion SPECT imaging improved accuracy for detection of obstructive coronary artery disease (CAD). We aimed to improve the clinical translatability of this artificial intelli...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Dec 3, 2024
Radiopharmaceutical cocktails have been developed over the years to treat cancer. Cocktails of agents are attractive because 1 radiopharmaceutical is unlikely to have the desired therapeutic effect because of nonuniform uptake by the targeted cells. ...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Sep 3, 2024
We propose strongly unrealistic data augmentation to improve the robustness of convolutional neural networks (CNNs) for automatic classification of dopamine transporter SPECT against the variability between sites and between cameras. A CNN was train...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Sep 3, 2024
Alzheimer disease (AD) exhibits spatially heterogeneous 3- or 4-repeat tau deposition across participants. Our overall goal was to develop an automated method to quantify the heterogeneous burden of tau deposition into a single number that would be c...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Jul 1, 2024
Transthyretin cardiac amyloidosis (ATTR CA) is increasingly recognized as a cause of heart failure in older patients, with Tc-pyrophosphate imaging frequently used to establish the diagnosis. Visual interpretation of SPECT images is the gold standard...