IEEE transactions on bio-medical engineering
Apr 13, 2016
Sparse learning has been widely investigated for analysis of brain images to assist the diagnosis of Alzheimer's disease and its prodromal stage, i.e., mild cognitive impairment. However, most existing sparse learning-based studies only adopt cross-s...
Alzheimer's disease is a degenerative brain disease that results in cardinal memory deterioration and significant cognitive impairments. The early treatment of Alzheimer's disease can significantly reduce deterioration. Early diagnosis is difficult, ...
International journal of neural systems
Apr 4, 2016
Computer Aided Diagnosis (CAD) constitutes an important tool for the early diagnosis of Alzheimer's Disease (AD), which, in turn, allows the application of treatments that can be simpler and more likely to be effective. This paper explores the constr...
IEEE journal of biomedical and health informatics
Mar 4, 2016
Functional magnetic resonance imaging (fMRI) is one of the most promising noninvasive techniques for early Alzheimer's disease (AD) diagnosis. In this paper, we explore the application of different machine learning techniques to the classification of...
IEEE transactions on neural networks and learning systems
Feb 24, 2016
Understanding the progression of chronic diseases can empower the sufferers in taking proactive care. To predict the disease status in the future time points, various machine learning approaches have been proposed. However, a few of them jointly cons...
Multivariate pattern analysis techniques have been increasingly used over the past decade to derive highly sensitive and specific biomarkers of diseases on an individual basis. The driving assumption behind the vast majority of the existing methodolo...
Normalization of feature vector values is a common practice in machine learning. Generally, each feature value is standardized to the unit hypercube or by normalizing to zero mean and unit variance. Classification decisions based on support vector ma...
As shown in the literature, methods based on multiple templates usually achieve better performance, compared with those using only a single template for processing medical images. However, most existing multi-template based methods simply average or ...
Insulin resistance is a risk factor for Alzheimer's disease (AD), although its role in AD etiology is unclear. We assessed insulin resistance using fasting and insulin-stimulated measures in 51 elderly subjects with no dementia (ND; n = 37) and with ...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Nov 5, 2015
The diagnosis of Alzheimer's disease (AD) requires a variety of medical tests, which leads to huge amounts of multivariate heterogeneous data. Such data are difficult to compare, visualize, and analyze due to the heterogeneous nature of medical tests...