AIMC Topic: Animals
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Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping.
ACS nano
Jun 4, 2025
Current clinical treatment of pulmonary diseases requires an advanced three-dimensional (3D) pathological atlas of the microenvironment, particularly the trachea, which is predominantly affected by lung disorders. In this study, the gridded cyclodext...
Weakly supervised learning through box annotations for pig instance segmentation.
Scientific reports
Jun 4, 2025
Pig instance segmentation is a critical component of smart pig farming, serving as the basis for advanced applications such as health monitoring and weight estimation. However, existing methods typically rely on large volumes of precisely labeled mas...
Deep learning based rapid X-ray fluorescence signal extraction and image reconstruction for preclinical benchtop X-ray fluorescence computed tomography applications.
Scientific reports
Jun 4, 2025
Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (...
Digital removal of dermal denticle layer using geometric AI from 3D CT scans of shark craniofacial structures enhances anatomical precision.
Scientific reports
Jun 4, 2025
Craniofacial morphometrics in sharks provide crucial insights into evolutionary history, geographical variation, sexual dimorphism, and developmental patterns. However, the fragile cartilaginous nature of shark craniofacial skeleton poses significant...
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Nature communications
Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Clinical Management of Wasp Stings Using Large Language Models: Cross-Sectional Evaluation Study.
Journal of medical Internet research
Jun 4, 2025
BACKGROUND: Wasp stings are a significant public health concern in many parts of the world, particularly in tropical and subtropical regions. The venom of wasps contains a variety of bioactive compounds that can lead to a wide range of clinical effec...
Rational Design of Safer Inorganic Nanoparticles via Mechanistic Modeling-Informed Machine Learning.
ACS nano
Jun 3, 2025
The safety of inorganic nanoparticles (NPs) remains a critical challenge for their clinical translation. To address this, we developed a machine learning (ML) framework that predicts NP toxicity both and , leveraging physicochemical properties and e...
DeepGFT: identifying spatial domains in spatial transcriptomics of complex and 3D tissue using deep learning and graph Fourier transform.
Genome biology
Jun 3, 2025
The rapid advancements in spatially resolved transcriptomics (SRT) enable the characterization of gene expressions while preserving spatial information. However, high dropout rates and noise hinder accurate spatial domain identification for understan...
Identifying a gene signature for age-related hearing loss through machine learning and revealing the effect of the CTSS on the mice cochlea.
Biogerontology
Jun 3, 2025
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA se...
Deep learning-based electrical impedance spectroscopy analysis for malignant and potentially malignant oral disorder detection.
Scientific reports
Jun 3, 2025
Electrical impedance spectroscopy (EIS) is a powerful tool used to investigate the properties of materials and biological tissues. This study presents one of the first applications of EIS for the detection and classification of oral potentially malig...
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