AIMC Topic: Animals

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Proteomics and Machine Learning-Based Approach to Decipher Subcellular Proteome of Mouse Heart.

Molecular & cellular proteomics : MCP
Protein compartmentalization to distinctive subcellular niches is critical for cardiac function and homeostasis. Here, we employed a rapid and robust workflow based on differential centrifugal-based fractionation with mass spectrometry-based proteomi...

AI-driven framework to map the brain metabolome in three dimensions.

Nature metabolism
High-resolution spatial imaging is transforming our understanding of foundational biology. Spatial metabolomics is an emerging field that enables the dissection of the complex metabolic landscape and heterogeneity from a thin tissue section. Currentl...

Robust resolution improvement of 3D UTE-MR angiogram of normal vasculatures using super-resolution convolutional neural network.

Scientific reports
Contrast-enhanced UTE-MRA provides detailed angiographic information but at the cost of prolonged scanning periods, which may impose moving artifacts and affect the promptness of diagnosis and treatment of time-sensitive diseases like stroke. This st...

Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning.

Frontiers in endocrinology
BACKGROUND: Diabetic cardiomyopathy (DC) is a serious complication in patients with type 1 diabetes mellitus and has become a growing public health problem worldwide. There is evidence that endoplasmic reticulum stress (ERS) is involved in the pathog...

Robot-Assisted Stereotactic Microinjection Method for Precision Cell Transplantation in Rat and Canine Models.

Cell transplantation
Cell transplantation is a promising approach for addressing neurodegenerative conditions. In this study, we developed a robot-assisted stereotactic microinjection system for transplanting cells. We evaluated the factors that affect cellular graft via...

Design and application of ISSA-BP neural network model for predicting soft tissue relaxation force.

Acta of bioengineering and biomechanics
: Accurate biomechanical modeling is crucial for enhancing the realism of virtual surgical training. This study addressed the computational cost and complexity associated with traditional viscoelastic models by incorporating neural network algorithms...

Probing the dark chemical matter against PDE4 for the management of psoriasis using in silico, in vitro and in vivo approach.

Molecular diversity
The potential downsides for the present treatment for psoriasis are drug resistance, reduced efficacy, risk of mental episodes, and drug interactions. Hence, this study aims to discover a new drug for psoriasis by considering global research efforts ...

Histopathology image classification based on semantic correlation clustering domain adaptation.

Artificial intelligence in medicine
Deep learning has been successfully applied to histopathology image classification tasks. However, the performance of deep models is data-driven, and the acquisition and annotation of pathological image samples are difficult, which limit the model's ...

Artificial intelligence in anti-obesity drug discovery: unlocking next-generation therapeutics.

Drug discovery today
Obesity, a multifactorial disease linked to severe health risks, requires innovative treatments beyond lifestyle changes and current medications. Existing anti-obesity drugs face limitations regarding efficacy, side effects, weight regain and high co...

Miniature origami robot for various biological micromanipulations.

Nature communications
Robotic micromanipulation is widely applied in biological research and medical procedures, providing a level of operational precision and stability beyond human capability. Compared with traditional micromanipulators that require assembly from many p...