BACKGROUND: Numerous studies have investigated the role of macrophages in the pathogenesis of diabetic cardiomyopathy (DCM); however, the underlying mechanisms remain unclear.
The 5' UTR is critical for mRNA stability and translation efficiency in therapeutics. We developed UTR-Insight, a model integrating a pretrained language model with a CNN-Transformer architecture, explaining 89.1% of the mean ribosome load (MRL) vari...
. Deep learning tools applied to high-resolution neurophysiological data have significantly progressed, offering enhanced decoding, real-time processing, and readability for practical applications. However, the design of artificial neural networks to...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Feb 3, 2025
Unexpected toxicity has become a significant obstacle to drug candidate development, accounting for 30% of drug discovery failures. Traditional toxicity assessment through animal testing is costly and time-consuming. Big data and artificial intellige...
Doping control screening analyses usually involve visual inspection of extracted ion chromatograms (EIC) by a trained analytical chemist, followed by further investigations if needed. This task is both highly repetitive and time-consuming, given the ...
Cells are regulated at multiple levels, from regulations of individual genes to interactions across multiple genes. Some recent neural network models can connect molecular changes to cellular phenotypes, but their design lacks modeling of regulatory ...
In the wagyu industry worldwide, high-quality marbling beef is produced by promoting intramuscular fat deposition during cattle fattening stage through dietary vitamin A control. Thus, however, cattle become susceptible to either vitamin A deficiency...
The selection of high-performing cell lines is crucial for biopharmaceutical production but is often time-consuming and labor-intensive. We investigated label-free multimodal nonlinear optical microscopy for non-perturbative profiling of biopharmaceu...
With bio-medical wearables becoming an essential part of Internet of Medical things (IoMT) for monitoring the health of workers, patients and others in different environments, antenna play a pivotal role in such wearables. In this communication, a no...
Expert opinion on drug metabolism & toxicology
Feb 2, 2025
INTRODUCTION: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Hepatotoxicity typically occurs only in a subset of individuals after prolonged exposure and constitutes a major risk factor for the termination of drug develop...
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