The need for effective biomonitoring in wastewater has become clear due to the impracticality of continuously tracking all chemicals and emerging contaminants in the aquatic exposome. Effect-based biomonitoring provides a cost-effective solution. The...
Proceedings of the National Academy of Sciences of the United States of America
Nov 17, 2025
Throughout Earth's history, organic molecules from both abiogenic and biogenic sources have been buried in sedimentary rocks. Most of these organic molecules have been significantly altered by geologic processes through deep time. Nonetheless, the na...
Critical periods (CPs) during the development of neural networks are widely documented. Activity manipulation during open CPs leads to debilitating effects to the mature neural network. Detailed understanding of the contribution of CPs to network dev...
This study aimed to investigate the relationship between methylation quantitative trait loci (meQTL) and lung adenocarcinoma (LUAD) susceptibility. Candidate SNPs linked to differentially methylated CpG sites in LUAD were identified through meQTL dat...
Therapeutic resistance remains a defining challenge in oncology, limiting the durability of current therapies and contributing to disease relapse and poor patient outcomes. This review systematically integrates recent progress in understanding the mo...
International journal of pharmaceutics
Nov 15, 2025
Oral cancer remains one of the most aggressive malignancies worldwide, with high recurrence and limited treatment outcomes due to late diagnosis and ineffective targeting of tumor microenvironments. Stem cell-based hydrogel therapies have emerged as ...
International journal of pharmaceutics
Nov 15, 2025
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecules, peptides...
Journal of molecular neuroscience : MN
Nov 15, 2025
Spinal cord injury (SCI), a traumatic type of central nervous system injury, is closely associated with neuronal apoptosis. However, the specific biomarkers and regulatory mechanisms of neuronal apoptosis in SCI patients remain unclear. In this study...
BACKGROUND: Glioblastoma (GBM) is no longer regarded as a single disease, as distinct molecular subgroups exist, with the mesenchymal (MES) having the worst prognosis. As such, there is a critical need for noninvasive methods to determine GBM molecul...
PURPOSE: Increasing evidence has indicated a role of oxidative stress in the pathogenesis of biliary atresia (BA). This study aimed to identify key oxidative stress-related biomarkers in BA and explore their therapeutic potential.
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