The widespread use of plastic agricultural films necessitates a thorough evaluation of environmental risks posed by soil microplastics (MPs). While the intestinal tract is a critical site for MP interactions in soil organisms, current research predom...
Chromatin and DNA modifications mediate the transcriptional activity of lineage-specifying enhancers, but recent work challenges the dogma that joint chromatin accessibility and DNA demethylation are prerequisites for transcription. To understand thi...
Journal of chemical information and modeling
May 26, 2025
Blood-brain barrier (BBB) permeability plays a crucial role in determining drug efficacy in the brain, with the brain-to-plasma unbound partition coefficient () recognized as a key parameter of BBB permeability in drug development. However, data are...
Journal of chemical information and modeling
May 26, 2025
Prediction of drug-induced nephrotoxicity is an important task in the drug discovery and development pipeline. Chemical information-based machine learning models are used in general for nephrotoxicity prediction as a part of computational modeling. C...
Zhen ci yan jiu = Acupuncture research
May 25, 2025
The holistic philosophy of traditional Chinese medicine (TCM) embodied in acupuncture therapy has gained novel insights within the neuroimmune regulatory framework. Its mechanistic framework encompasses 3 pivotal dimensions: 1) Acupuncture stimulatio...
The incidence of hypotension after a lumbosacral epidural in dogs depends on the volume of local anaesthetic administered. So far, there are no reports comparing both methods used to calculate this volume-body weight (BW) and occipito-coccygeal lengt...
Jellyfish cyborgs present a promising avenue for soft robotic systems, leveraging the natural energy-efficiency and adaptability of biological systems. Here we present an approach for predicting and controlling jellyfish locomotion by harnessing the ...
Arthropods have intricate compound eyes and optic neuropils, exhibiting exceptional visual capabilities. Combining the strengths of digital imaging with the features of natural arthropod visual systems offers a promising approach to harness wide-angl...
Brain computer interfaces (BCIs) require substantial cognitive flexibility to optimize control performance. Remarkably, learning this control is rapid, suggesting it might be mediated by neuroplasticity mechanisms operating on very short time scales....
Nonhuman primate (NHP) neuroanatomy and cognitive complexity make NHPs ideal models to study human neurobiology and disease. However, NHP circuit-function investigations are limited by the availability of molecular reagents that are effective in NHPs...
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