AIMC Topic: ATP Binding Cassette Transporter, Subfamily B

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Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model.

The AAPS journal May 18, 2021
The mechanistic neuropharmacokinetic (neuroPK) model was established to predict unbound brain-to-plasma partitioning (K) by considering in vitro efflux activities of multiple drug resistance 1 (MDR1) and breast cancer resistance protein (BCRP). Herei...
Rats Predictive Value of Tests Dogs Blood-Brain Barrier Animals Male Models, Animal ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily G, Member 2 Models, Biological Madin Darby Canine Kidney Cells Datasets as Topic Machine Learning
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Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein.

Molecular pharmaceutics Apr 16, 2019
For efficient drug discovery and screening, it is necessary to simplify P-glycoprotein (P-gp) substrate assays and to provide in silico models that predict the transport potential of P-gp. In this study, we developed a simplified in vitro screening m...
Animals Drug Discovery Swine Machine Learning Computer Simulation Reproducibility of Results Cell Membrane Permeability Protein Transport Intestinal Absorption ATP Binding Cassette Transporter, Subfamily B LLC-PK1 Cells Transfection Biological Availability Data Accuracy ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Evaluation, Preclinical Central Nervous System Agents
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Boosted feature selectors: a case study on prediction P-gp inhibitors and substrates.

Journal of computer-aided molecular design Oct 26, 2018
Feature selection is commonly used as a preprocessing step to machine learning for improving learning performance, lowering computational complexity and facilitating model interpretation. This paper proposes the application of boosting feature select...
Ligands Quantitative Structure-Activity Relationship ATP Binding Cassette Transporter, Subfamily B Support Vector Machine Decision Trees Molecular Structure Machine Learning Algorithms Protein Binding
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Artificial neural network model for predicting the bioavailability of tacrolimus in patients with renal transplantation.

PloS one Apr 5, 2018
The objective of the current study was to explore the role of ABCB1 and CYP3A5 genetic polymorphisms in predicting the bioavailability of tacrolimus and the risk for post-transplant diabetes. Artificial neural network (ANN) and logistic regression (L...
Biological Availability Cytochrome P-450 CYP3A ATP Binding Cassette Transporter, Subfamily B Genotype Computational Biology Tacrolimus Middle Aged Adolescent Polymorphism, Single Nucleotide Neural Networks, Computer Kidney Transplantation Female Young Adult Adult Male Humans
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Three- and four-class classification models for P-glycoprotein inhibitors using counter-propagation neural networks.

SAR and QSAR in environmental research Jan 14, 2015
P-glycoprotein (P-gp) is an ATP binding cassette (ABC) transporter that helps to protect several certain human organs from xenobiotic exposure. This efflux pump is also responsible for multi-drug resistance (MDR), an issue of the chemotherapy approac...
ATP Binding Cassette Transporter, Subfamily B Drug Resistance, Multiple Databases, Chemical Cytochrome P-450 CYP3A Inhibitors Neural Networks, Computer Computer Simulation Structure-Activity Relationship
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Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.

Clinical laboratory Sep 1, 2016
BACKGROUND: ATP-binding cassette transporters (ABC) gene polymorphisms are associated with various biological functions, including hepatitis C virus (HCV) infection. This study aims to explore the impact of ABC transporters polymorphisms on HCV viral...
ATP-Binding Cassette Transporters ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B Hepacivirus Hepatitis C, Chronic Gene Frequency ATP Binding Cassette Transporter, Subfamily B, Member 11 ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily G, Member 5 Polymorphism, Single Nucleotide Genotype Lipoproteins Interleukins Neoplasm Proteins ATP Binding Cassette Transporter, Subfamily B, Member 1 Male Middle Aged Viral Load Humans Female
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Generalized Multifactor Dimensionality Reduction (GMDR) Analysis of Drug-Metabolizing Enzyme-Encoding Gene Polymorphisms may Predict Treatment Outcomes in Indian Breast Cancer Patients.

World journal of surgery Jul 1, 2016
BACKGROUND: Prediction of response and toxicity of chemotherapy can help personalize the treatment and choose effective yet non-toxic treatment regimen for a breast cancer patient. Interplay of variations in various drug-metabolizing enzyme (DME)-enc...
Aged Adult Breast Neoplasms Middle Aged Polymorphism, Single Nucleotide Genotype Humans Female Cytochrome P-450 CYP2C19 Multifactor Dimensionality Reduction Logistic Models Chemotherapy, Adjuvant ATP Binding Cassette Transporter, Subfamily B
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