AIMC Topic: Automation, Laboratory
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Adapting a Low-Cost Selective Compliant Articulated Robotic Arm for Spillage Avoidance.
Journal of laboratory automation
Feb 16, 2016
Flexible automation systems provide the needed adaptability to serve shorter-term projects and specialty applications in biochemical analysis. A low-cost selective compliant articulated robotic arm designed for liquid spillage avoidance is developed ...
Fully automatized high-throughput enzyme library screening using a robotic platform.
Biotechnology and bioengineering
Feb 3, 2016
A fully automatized robotic platform has been established to facilitate high-throughput screening for protein engineering purposes. This platform enables proper monitoring and control of growth conditions in the microtiter plate format to ensure prec...
Active machine learning-driven experimentation to determine compound effects on protein patterns.
eLife
Feb 3, 2016
High throughput screening determines the effects of many conditions on a given biological target. Currently, to estimate the effects of those conditions on other targets requires either strong modeling assumptions (e.g. similarities among targets) or...
Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach.
Environmental and molecular mutagenesis
Jan 13, 2016
Several endpoints associated with cellular responses to DNA damage as well as overt cytotoxicity were multiplexed into a miniaturized, "add and read" type flow cytometric assay. Reagents included a detergent to liberate nuclei, RNase and propidium io...
Automated Classification and Cluster Visualization of Genotypes Derived from High Resolution Melt Curves.
PloS one
Nov 25, 2015
INTRODUCTION: High Resolution Melting (HRM) following PCR has been used to identify DNA genotypes. Fluorescent dyes bounded to double strand DNA lose their fluorescence with increasing temperature, yielding different signatures for different genotype...
Managing bioengineering complexity with AI techniques.
Bio Systems
Sep 3, 2015
Our capabilities for systematic design and engineering of biological systems are rapidly increasing. Effectively engineering such systems, however, requires the synthesis of a rapidly expanding and changing complex body of knowledge, protocols, and m...
Computer-Assisted Transgenesis of Caenorhabditis elegans for Deep Phenotyping.
Genetics
Jul 10, 2015
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of geneti...
An unsupervised feature learning framework for basal cell carcinoma image analysis.
Artificial intelligence in medicine
Apr 23, 2015
OBJECTIVE: The paper addresses the problem of automatic detection of basal cell carcinoma (BCC) in histopathology images. In particular, it proposes a framework to both, learn the image representation in an unsupervised way and visualize discriminati...
Pathology, Clinical
Discriminant Analysis
Biopsy
Image Interpretation, Computer-Assisted
Reproducibility of Results
ROC Curve
Decision Support Systems, Clinical
Predictive Value of Tests
Area Under Curve
Staining and Labeling
Automation, Laboratory
Unsupervised Machine Learning
Humans
Skin Neoplasms
Decision Support Techniques
Carcinoma, Basal Cell
An automated high-throughput SPE micro-elution method for perfluoroalkyl substances in human serum.
Analytical and bioanalytical chemistry
Mar 21, 2015
An automated high-throughput solid phase extraction (SPE) micro-elution method for 8 perfluorosulfonic acids, 11 perfluorocarboxylic acids and fluorooctane sulfonamide in human serum was developed. Importance was attached to the application of small ...
Automated device for rapid sample cooling via controlled submersion.
Cryobiology
Jun 1, 2025
An automated device is described which enables programmable submersion in liquid nitrogen to enable rapid specimen cooling for vitrification applications. The device presented here is low-cost, portable, and compatible with a range of cryogenic conta...
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