Neuromodulation modalities are used as effective treatments for some brain disorders. Non-invasive deep brain stimulation (NDBS) via temporally interfering electric fields has emerged recently as a non-invasive strategy for electrically stimulating d...
In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal models of glaucoma. We adapted deep learning to regress pixelwise axon count de...
BACKGROUND: The myelin sheath produced by glial cells insulates the axons, and supports the function of the nervous system. Myelin sheath degeneration causes neurodegenerative disorders, such as multiple sclerosis (MS). There are no therapies for MS ...
Recently, neuromorphic sensors, which convert analogue signals to spiking frequencies, have been reported for neurorobotics. In bio-inspired systems these sensors are connected to the main neural unit to perform post-processing of the sensor data. ...
The intra-axonal water exchange time (τ), a parameter associated with axonal permeability, could be an important biomarker for understanding and treating demyelinating pathologies such as Multiple Sclerosis. Diffusion-Weighted MRI (DW-MRI) is sensiti...
The tri-synaptic pathway in the mammalian hippocampus enables cognitive learning and memory. Despite decades of reports on anatomy and physiology, the functional architecture of the hippocampal network remains poorly understood in terms of the dynami...
The Hodgkin-Huxley model, decades after its first presentation, is still a reference model in neuroscience as it has successfully reproduced the electrophysiological activity of many organisms. The primary signal in the model represents the membrane ...
Neural networks : the official journal of the International Neural Network Society
33639581
In spiking neural P (SN P) systems, neurons are interconnected by means of synapses, and they use spikes to communicate with each other. However, in biology, the complex structure of dendritic tree is also an important part in the communication schem...
Ischemic stroke is a leading cause of disability world-wide. Mounting evidence supports neuromuscular pathology following stroke, yet mechanisms of dysfunction and therapeutic action remain undefined. The objectives of our study were to investigate n...
Axonal degeneration (AxD) is a pathological hallmark of many neurodegenerative diseases. Deciphering the morphological patterns of AxD will help to understand the underlying mechanisms and develop effective therapies. Here, we evaluated the progressi...