AIMC Topic: Biological Specimen Banks
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Quantitative CMR population imaging on 20,000 subjects of the UK Biobank imaging study: LV/RV quantification pipeline and its evaluation.
Medical image analysis
May 25, 2019
Population imaging studies generate data for developing and implementing personalised health strategies to prevent, or more effectively treat disease. Large prospective epidemiological studies acquire imaging for pre-symptomatic populations. These st...
Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants.
PloS one
May 15, 2019
BACKGROUND: Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone of preventative cardiology. Risk prediction models currently recommended by clinical guidelines are typically based on a limited number of predictors with sub-op...
Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide.
Molecular psychiatry
Jan 4, 2019
Suicide accounts for nearly 800,000 deaths per year worldwide with rates of both deaths and attempts rising. Family studies have estimated substantial heritability of suicidal behavior; however, collecting the sample sizes necessary for successful ge...
Mind the Gap: From Tool to Knowledge Base.
Biopreservation and biobanking
Aug 13, 2018
With the ethical, legal, and societal issues (ELSI) Knowledge Base, we introduce a key element of the Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium (BBMRI-ERIC) Common Service ELSI, which pr...
Statistical machine learning of sleep and physical activity phenotypes from sensor data in 96,220 UK Biobank participants.
Scientific reports
May 21, 2018
Current public health guidelines on physical activity and sleep duration are limited by a reliance on subjective self-reported evidence. Using data from simple wrist-worn activity monitors, we developed a tailored machine learning model, using balanc...
Automated arteriole and venule classification using deep learning for retinal images from the UK Biobank cohort.
Computers in biology and medicine
Sep 8, 2017
The morphometric characteristics of the retinal vasculature are associated with future risk of many systemic and vascular diseases. However, analysis of data from large population based studies is needed to help resolve uncertainties in some of these...
OBIB-a novel ontology for biobanking.
Journal of biomedical semantics
May 2, 2016
BACKGROUND: Biobanking necessitates extensive integration of data to allow data analysis and specimen sharing. Ontologies have been demonstrated to be a promising approach in fostering better semantic integration of biobank-related data. Hitherto no ...
Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants.
PloS one
Apr 25, 2016
UK Biobank includes 502,649 middle- and older-aged adults from the general population who have undergone detailed phenotypic assessment. The majority of participants completed tests of cognitive functioning, and on average four years later a sub-grou...
Nonlinear Associations of Accelerometer-Based Sedentary Time With Cognitive Functions in the UK Biobank.
The journals of gerontology. Series B, Psychological sciences and social sciences
Jun 10, 2025
OBJECTIVES: Device-based sedentary time shows a nonlinear association with incident dementia among older adults. However, associations between sedentary time and cognitive performance have been inconsistent. We examined potential nonlinear associatio...
Brain Aging in Patients With Cardiovascular Disease From the UK Biobank.
Human brain mapping
Jun 1, 2025
The brain undergoes complex but normal structural changes during the aging process in healthy adults, whereas deviations from the normal aging patterns of the brain can be indicative of various conditions as well as an increased risk for the developm...
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