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Biological Specimen Banks

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Risk prediction for cardiovascular disease using ECG data in the China kadoorie biobank.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
We set out to use machine learning techniques to analyse ECG data to improve risk evaluation of cardiovascular disease in a very large cohort study of the Chinese population. We performed this investigation by (i) detecting "abnormality" using 3 one-...

Semi-automated evaluation of biomedical ontologies for the biobanking domain based on competency questions.

Studies in health technology and informatics
BACKGROUND: Biosample collections and biobank information systems have become a key enabler for medical research. Therefore it is important to identify potentially relevant ontologies to semantically enrich information related to the biobanking domai...

OBIB-a novel ontology for biobanking.

Journal of biomedical semantics
BACKGROUND: Biobanking necessitates extensive integration of data to allow data analysis and specimen sharing. Ontologies have been demonstrated to be a promising approach in fostering better semantic integration of biobank-related data. Hitherto no ...

Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants.

PloS one
UK Biobank includes 502,649 middle- and older-aged adults from the general population who have undergone detailed phenotypic assessment. The majority of participants completed tests of cognitive functioning, and on average four years later a sub-grou...

Automated arteriole and venule classification using deep learning for retinal images from the UK Biobank cohort.

Computers in biology and medicine
The morphometric characteristics of the retinal vasculature are associated with future risk of many systemic and vascular diseases. However, analysis of data from large population based studies is needed to help resolve uncertainties in some of these...

Statistical machine learning of sleep and physical activity phenotypes from sensor data in 96,220 UK Biobank participants.

Scientific reports
Current public health guidelines on physical activity and sleep duration are limited by a reliance on subjective self-reported evidence. Using data from simple wrist-worn activity monitors, we developed a tailored machine learning model, using balanc...

Mind the Gap: From Tool to Knowledge Base.

Biopreservation and biobanking
With the ethical, legal, and societal issues (ELSI) Knowledge Base, we introduce a key element of the Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium (BBMRI-ERIC) Common Service ELSI, which pr...

Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants.

PloS one
BACKGROUND: Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone of preventative cardiology. Risk prediction models currently recommended by clinical guidelines are typically based on a limited number of predictors with sub-op...

Significant shared heritability underlies suicide attempt and clinically predicted probability of attempting suicide.

Molecular psychiatry
Suicide accounts for nearly 800,000 deaths per year worldwide with rates of both deaths and attempts rising. Family studies have estimated substantial heritability of suicidal behavior; however, collecting the sample sizes necessary for successful ge...

Quantitative CMR population imaging on 20,000 subjects of the UK Biobank imaging study: LV/RV quantification pipeline and its evaluation.

Medical image analysis
Population imaging studies generate data for developing and implementing personalised health strategies to prevent, or more effectively treat disease. Large prospective epidemiological studies acquire imaging for pre-symptomatic populations. These st...