AIMC Topic: AMP-Activated Protein Kinases

Clear Filters Showing 1 to 8 of 8 articles

Machine learning developed LKB1-AMPK signaling related signature for prognosis and drug sensitivity in hepatocellular carcinoma.

Scientific reports Jul 1, 2025
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, posing a significant threat to the life and health of people globally. LKB1-AMPK signaling pathway plays a significant role in the regulation of cellular metabolism, prolifera...
Prognosis Biomarkers, Tumor Cell Line, Tumor Liver Neoplasms Humans Machine Learning Signal Transduction Protein Serine-Threonine Kinases AMP-Activated Protein Kinases AMP-Activated Protein Kinase Kinases Carcinoma, Hepatocellular Gene Expression Regulation, Neoplastic Cell Proliferation
View on PubMed DOI

Specneuzhenide improves bleomycin-induced pulmonary fibrosis in mice via AMPK-dependent reduction of PD-L1.

Phytomedicine : international journal of phytotherapy and phytopharmacology Dec 30, 2023
BACKGROUND: Pulmonary fibrosis (PF) is an escalating global health issue, characterized by rising rates of morbidity and mortality annually. Consequently, further investigation of potential damage mechanisms and potential preventive strategies for PF...
Bleomycin Cell Line Transforming Growth Factor beta1 Mice, Inbred C57BL Molecular Docking Simulation Pulmonary Fibrosis Fibroblasts Animals AMP-Activated Protein Kinases Male B7-H1 Antigen Lung Mice Disease Models, Animal Epithelial-Mesenchymal Transition
View on PubMed DOI

Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Machine Learning Inflammatory Bowel Diseases Reproducibility of Results Animals Humans Artificial Intelligence Organoids AMP-Activated Protein Kinases Multigene Family Gene Expression Regulation Molecular Targeted Therapy Likelihood Functions Dextran Sulfate Colitis Cohort Studies Disease Models, Animal Mice Mice, Inbred C57BL Treatment Outcome Intestinal Mucosa Mice, Knockout
View on PubMed DOI

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.

Scientific reports Feb 28, 2018
AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines....
Drug Screening Assays, Antitumor AMP-Activated Protein Kinases Colonic Neoplasms Biological Ontologies Cell Line, Tumor Biological Products Cell Survival Protein Kinase Inhibitors Humans
View on PubMed DOI

Putative identification of components in Zengye Decoction and their effects on glucose consumption and lipogenesis in insulin-induced insulin-resistant HepG2 cells.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Dec 12, 2017
Zengye Decoction (ZYD) is a well-known traditional medicine in China used for treating diseases associated with "Yin deficiency" such as diabetes. However, little information is available on its components, pharmacological effects and underlying mech...
Glycolysis Insulin Resistance Hep G2 Cells Drugs, Chinese Herbal Humans AMP-Activated Protein Kinases Insulin Glucose Lipogenesis
View on PubMed DOI

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.

Oncotarget Apr 18, 2017
We demonstrate that model-based unsupervised learning can uniquely discriminate single-cell subpopulations by their gene expression distributions, which in turn allow us to identify specific genes for focused functional studies. This method was appli...
Cluster Analysis Unsupervised Machine Learning AMP-Activated Protein Kinases Metformin Gene Knockdown Techniques cdc42 GTP-Binding Protein Breast Neoplasms Computational Biology Gene Expression Profiling Gene Expression Regulation, Neoplastic Cell Line, Tumor Signal Transduction Cell Movement Humans Female
View on PubMed DOI

Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.

Iranian journal of allergy, asthma, and immunology Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
Tumor Necrosis Factor-alpha Animals Male Lung Real-Time Polymerase Chain Reaction RNA, Messenger Metformin Myeloid Differentiation Factor 88 Toll-Like Receptor 4 Peroxidase Acute Lung Injury Lipopolysaccharides Rats, Wistar Blotting, Western Rats NF-kappa B Hypoglycemic Agents AMP-Activated Protein Kinases
View on PubMed

[Role of interleukin-17 in alveolar fluid clearance in mice with acute lung injury].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University Apr 20, 2016
OBJECTIVE: To investigate the role of interleukin-17 (IL-17) in alveolar fluid clearance in mice with acute lung injury (ALI) and explore the possible mechanism.
Gene Knockout Techniques AMP-Activated Protein Kinases Bronchoalveolar Lavage Fluid Acute Lung Injury Epithelial Sodium Channels Lipopolysaccharides Protein Serine-Threonine Kinases Interleukin-8 Animals Lung Interleukin-17 Mice
View on PubMed DOI
Popular Topics
Recent Journals