Prostate cancer bone metastasis (PCBM) is a highly lethal condition with limited survival. Accurate survival prediction is essential for managing these typically incurable patients. However, existing clinical models lack precision. This study seeks t...
Despite improvements, prognosis in osteosarcoma patients remains poor, making it essential to identify additional and more robust therapeutic targets. Non-apoptotic receptor-mediated cell death (RCD), which plays a crucial role in the pathogenesis of...
Classifying chondroid tumors is an essential step for effective treatment planning. Recently, with the advances in computer-aided diagnosis and the increasing availability of medical imaging data, automated tumor classification using deep learning sh...
BACKGROUND: Artificial Intelligence is transforming medical imaging, particularly in the analysis of bone metastases (BM), a serious complication of advanced cancers. Machine learning and deep learning techniques offer new opportunities to improve de...
BACKGROUND: [F]FDG PET/CT scan combined with [F]PSMA-1007 PET/CT scan is commonly conducted for detecting bone metastases in prostate cancer (PCa). However, it is expensive and may expose patients to more radiation hazards. This study explores deep l...
OBJECTIVE: PET image analysis provides tumor heterogeneity data related to neoadjuvant chemotherapy response (NACR) and metastatic risk in osteosarcoma. Ki-67 expression is used to predict metastasis. The accuracy of prediction models with image quan...
Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
May 3, 2025
BACKGROUND: Advancements in diagnostic and therapeutic modalities for giant cell tumors of bone (GCTB) have introduced molecular and radiological tools that refine clinical decision-making. H3.3 G34W immunohistochemical staining has become a routine ...
INTRODUCTION: High-dose methotrexate is a typical chemotherapy that is widely used in the treatment of osteosarcoma. However, the unique dose-response relationship of methotrexate makes its treatment window relatively narrow, and its clinical use is ...
BACKGROUND: Artificial intelligence (AI) is increasingly being explored for its potential role in medical diagnostics. ChatGPT-4, a large language model (LLM) with image analysis capabilities, may assist in histopathological interpretation, but its a...
PURPOSE: Convolutional neural networks (CNNs) have been studied for detecting bone metastases on bone scans; however, the application of ConvNeXt and transformer models has not yet been explored. This study aims to evaluate the performance of various...
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