BACKGROUND: Major depressive disorder (MDD) is a widespread mental health issue, impacting spatial and temporal aspects of brain activity. The neural mechanisms behind MDD remain unclear. To address this gap, we introduce a novel measure, spatiotempo...
Primary angle-closure glaucoma (PACG) is a severe and irreversible blinding eye disease characterized by progressive retinal ganglion cell death. However, prior research has predominantly focused on static brain activity changes, neglecting the explo...
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) thalamotomy is an emerging technique for medication-refractory essential tremor (ET), but with variable outcomes. This study used pattern regression analysis to identify brain signatures p...
Auditory spatial attention detection (ASAD) seeks to determine which speaker in a surround sound field a listener is focusing on based on the one's brain biosignals. Although existing studies have achieved ASAD from a single-trial electroencephalogra...
BACKGROUND: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wa...
Performing mathematical calculations is a cognitive activity that can affect biological signals. This study aims to examine the changes in electroencephalogram (EEG) and electrocardiogram (ECG) signals of 36 healthy subjects during the performance of...
The concept of 'brain age', derived from neuroimaging data, serves as a crucial biomarker reflecting cognitive vitality and neurodegenerative trajectories. In the past decade, machine learning (ML) and deep learning (DL) integration has transformed t...
PURPOSE: Echo modulation curve (EMC) modeling enables accurate quantification of T relaxation times in multi-echo spin-echo (MESE) imaging. The standard EMC-T mapping framework, however, requires sufficient echoes and cumbersome pixel-wise dictionary...
BACKGROUND: In Huntington's disease clinical trials, recruitment and stratification approaches primarily rely on genetic load, cognitive and motor assessment scores. They focus less on in vivo brain imaging markers, which reflect neuropathology well ...
One-photon fluorescent calcium imaging helps understand brain functions by recording large-scale neural activities in freely moving animals. Automatic, fast, and accurate active neuron segmentation algorithms are essential to extract and interpret in...
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