Drug-induced liver injury (DILI) is a leading cause of clinical trial attrition and postmarketing withdrawal and a major contributor to acute liver failure. As regulators increasingly encourage human-relevant, nonanimal approaches, accurate and inter...
: Perfluorooctane sulphonate (PFOS) is a persistent environmental contaminant with well-documented hepatotoxic properties. Nicotinamide, the amide derivative of vitamin B3, is widely utilized as a nutritional supplement and exerts multiple biological...
Cholestatic liver injury is a complex adversity leading to the toxic accumulation of.noxious bile salts in the liver and systemic circulation. Cholestasis can be instigated by a plethora of chemicals originating from several applicability domains. Cu...
Phytomedicine : international journal of phytotherapy and phytopharmacology
Apr 11, 2025
BACKGROUND: Emodin, a hepatoprotective agent derived from various herbs, exhibits dual effects on liver injury, necessitating further investigation into its therapeutic and toxic properties. Traditional meta-analyses lack predictive capability for do...
Drug-induced liver injury (DILI) is a major cause of drug development failures and postmarket drug withdrawals, posing significant challenges to public health and pharmaceutical research. The biological mechanisms leading to DILI are highly complex a...
Drug-induced liver injury (DILI) toxicity is a condition when drugs have a destructive effect on the liver organ. The prediction of this toxicity becomes crucial in the drug development process to guarantee that drugs are safe from toxicity. Assessme...
Expert opinion on drug metabolism & toxicology
Feb 2, 2025
INTRODUCTION: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Hepatotoxicity typically occurs only in a subset of individuals after prolonged exposure and constitutes a major risk factor for the termination of drug develop...
PURPOSE: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. This study aims to develop an automatic machine learning (AutoML)...
BACKGROUND: Liver injury from drug-drug interactions (DDIs), notably with anti-tuberculosis drugs such as isoniazid, poses a significant safety concern. Electronic medical records contain comprehensive clinical information and have gained increasing ...
PURPOSE: Drug-induced liver injury, or DILI, affects numerous patients and also presents significant challenges in drug development. It has been attempted to predict DILI of a chemical by in silico approaches, including data-driven machine learning m...
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