Enhancing the understanding of attention-deficit/hyperactivity disorder (ADHD) by linking biological processes with behavioral manifestations is a primary objective of the Research Domain Criteria (RDoC) framework, which aims to transcend traditional...
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Aug 1, 2025
The use of artificial intelligence (AI) in pediatric and adolescent medicine offers numerous possibilities, particularly in the prevention of chronic diseases. AI-powered applications such as machine learning for the analysis of speech or movement pa...
Anorexia nervosa (AN), a severe eating disorder marked by extreme weight loss and malnutrition, leads to significant alterations in brain structure. This study used machine learning (ML) to estimate brain age from structural MRI scans and investigate...
The kidney is a target organ for the dysregulated host response to infection that defines sepsis, and acute kidney injury (AKI) is often an early manifestation of this response. Current sepsis criteria for adults (Sepsis-3) continue to include outmod...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
BACKGROUND: Accurate determination of B/T-cell lineage and the presence of the ETV6-RUNX1 translocation is critical for diagnosing acute lymphoblastic leukemia (ALL), as these factors influence treatment decisions and outcomes. However, these diagnos...
Computer methods and programs in biomedicine
Aug 1, 2025
BACKGROUND AND OBJECTIVE: Pneumonia is the leading cause of hospitalisation and mortality among children under five, particularly in low-resource settings. Accurate differentiation between viral and bacterial pneumonia is essential for guiding approp...
BACKGROUND: Screening for suicide ideation and suicide attempts is crucial for adolescents, yet accurately predicting these outcomes remains a significant challenge. The relationship between non-suicidal self-injury and suicide ideation and attempts ...
AIMS: Children in clinical settings are prone to anxiety due to developmental limitations, which hinders treatment progress. This systematic review and meta-analysis aimed to evaluate the efficacy of social robot interventions compared to routine car...
BACKGROUND: Suicide is the second leading cause of death among early adolescents, yet the first onset of suicide attempts during this critical developmental period remains poorly understood. This study aimed to identify key characteristics associated...
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