AIMC Topic: Clinical Trials as Topic

Clear Filters Showing 121 to 130 of 249 articles

Assessing the Scope and Predictors of Intentional Dose Non-adherence in Clinical Trials.

Therapeutic innovation & regulatory science
BACKGROUND: Although there is broad agreement that the accurate estimation of non-adherence rates in clinical trials is essential to determining the dose-response relationship, treatment safety and efficacy effects, no accurate estimates have ever be...

Automated quantification and architectural pattern detection of hepatic fibrosis in NAFLD.

Annals of diagnostic pathology
Accurate detection and quantification of hepatic fibrosis remain essential for assessing the severity of non-alcoholic fatty liver disease (NAFLD) and its response to therapy in clinical practice and research studies. Our aim was to develop an integr...

Oncology Research: Clinical Trial Management Systems, Electronic Medical Record, and Artificial Intelligence.

Seminars in oncology nursing
OBJECTIVE: To discuss the implications of electronic systems and regulations regarding the use of electronic systems implemented during the conduct of a clinical trial and identify the impact of such platforms on oncology nurses' responsible for prov...

Natural Language Processing for Mimicking Clinical Trial Recruitment in Critical Care: A Semi-Automated Simulation Based on the LeoPARDS Trial.

IEEE journal of biomedical and health informatics
Clinical trials often fail to recruit an adequate number of appropriate patients. Identifying eligible trial participants is resource-intensive when relying on manual review of clinical notes, particularly in critical care settings where the time win...

Will Artificial Intelligence for Drug Discovery Impact Clinical Pharmacology?

Clinical pharmacology and therapeutics
As the field of artificial intelligence and machine learning (AI/ML) for drug discovery is rapidly advancing, we address the question "What is the impact of recent AI/ML trends in the area of Clinical Pharmacology?" We address difficulties and AI/ML ...

Development of a system based on artificial intelligence to identify visual problems in children: study protocol of the TrackAI project.

BMJ open
INTRODUCTION: Around 70% to 80% of the 19 million visually disabled children in the world are due to a preventable or curable disease, if detected early enough. Vision screening in childhood is an evidence-based and cost-effective way to detect visua...

Key indicators of phase transition for clinical trials through machine learning.

Drug discovery today
A significant number of drugs fail during the clinical testing stage. To understand the attrition of drugs through the regulatory process, here we review and advance machine-learning (ML) and natural language-processing algorithms to investigate the ...

Improving Clinical Trial Participant Prescreening With Artificial Intelligence (AI): A Comparison of the Results of AI-Assisted vs Standard Methods in 3 Oncology Trials.

Therapeutic innovation & regulatory science
BACKGROUND: Delays in clinical trial enrollment and difficulties enrolling representative samples continue to vex sponsors, sites, and patient populations. Here we investigated use of an artificial intelligence-powered technology, Mendel.ai, as a mea...

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks.

Nature medicine
Intraoperative diagnosis is essential for providing safe and effective care during cancer surgery. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin staining of processed tissue is time, resource and labor intensive. M...