INTRODUCTION: There is a growing interest in leveraging artificial intelligence (AI) technologies to enhance various aspects of clinical trials. The goal of this systematic review is to assess the impact of implementing AI approaches on different asp...
International journal of medical informatics
Jan 16, 2025
BACKGROUND: Artificial Intelligence (AI) is transforming drug development and clinical trials, helping researchers find new treatments faster and personalize care for patients. By automating tasks like molecule screening and predicting treatment outc...
PURPOSE: Enhancing the speed and efficiency of clinical trial recruitment is a key objective across international health systems. This study aimed to use artificial intelligence (AI) applied in the Victorian Cancer Registry (VCR), a population-based ...
The journal of prevention of Alzheimer's disease
Jan 1, 2025
BACKGROUND: Investigators conducting clinical trials have an ethical, scientific, and regulatory obligation to protect the safety of trial participants. Traditionally, safety monitoring includes manual review and coding of adverse event data by exper...
Clinical pharmacology and therapeutics
Dec 25, 2024
Since the deep learning revolution of the early 2010s, significant efforts and billions of dollars have been invested in applying artificial intelligence (AI) to drug discovery and development (AIDD). However, despite high expectations, few AI-discov...
Annual review of pharmacology and toxicology
Dec 17, 2024
In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate therapeutic efficacy in clinical trials. The FDA Modernization Act 2.0 he...
International journal of medical informatics
Dec 4, 2024
BACKGROUND: As fundamental documents in clinical trials, clinical trial protocols are intended to ensure that trials are conducted according to the objectives set by researchers. The advent of large models with superior semantic performance compared ...
OBJECTIVE: To enhance the efficiency, quality, and innovation capability of clinical trials, this paper introduces a novel model called CTEC-AC (Clinical Trial Eligibility Criteria Automatic Classification), aimed at structuring clinical trial eligib...
BACKGROUND: Medical record review by a physician clinical events committee is the gold standard for identifying cardiovascular outcomes in clinical trials, but is labor-intensive and poorly reproducible. Automated outcome adjudication by artificial i...
OBJECTIVE: This study investigates the use of Large Language Models (LLMs) for matching patients to clinical trials (CTs) within an information retrieval pipeline. Our objective is to enhance the process of patient-trial matching by leveraging the se...
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