AIMC Topic: Clinical Trials as Topic
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A multimodal deep learning approach for the prediction of cognitive decline and its effectiveness in clinical trials for Alzheimer's disease.
Translational psychiatry
Feb 21, 2024
Alzheimer's disease is one of the most important health-care challenges in the world. For decades, numerous efforts have been made to develop therapeutics for Alzheimer's disease, but most clinical trials have failed to show significant treatment eff...
Opportunities for Improving Glaucoma Clinical Trials via Deep Learning-Based Identification of Patients with Low Visual Field Variability.
Ophthalmology. Glaucoma
Jan 29, 2024
PURPOSE: Develop and evaluate the performance of a deep learning model (DLM) that forecasts eyes with low future visual field (VF) variability, and study the impact of using this DLM on sample size requirements for neuroprotective trials.
Generative artificial intelligence empowers digital twins in drug discovery and clinical trials.
Expert opinion on drug discovery
Jan 8, 2024
INTRODUCTION: The concept of Digital Twins (DTs) translated to drug development and clinical trials describes virtual representations of systems of various complexities, ranging from individual cells to entire humans, and enables in silico simulation...
Deep learning models for automatic tumor segmentation and total tumor volume assessment in patients with colorectal liver metastases.
European radiology experimental
Dec 1, 2023
BACKGROUND: We developed models for tumor segmentation to automate the assessment of total tumor volume (TTV) in patients with colorectal liver metastases (CRLM).
A comparison of machine learning methods to find clinical trials for inclusion in new systematic reviews from their PROSPERO registrations prior to searching and screening.
Research synthesis methods
Sep 25, 2023
Searching for trials is a key task in systematic reviews and a focus of automation. Previous approaches required knowing examples of relevant trials in advance, and most methods are focused on published trial articles. To complement existing tools, w...
Initial Testing of Robotic Exoskeleton Hand Device for Stroke Rehabilitation.
Sensors (Basel, Switzerland)
Jul 12, 2023
The preliminary test results of a novel robotic hand rehabilitation device aimed at treatment for the loss of motor abilities in the fingers and thumb due to stroke are presented. This device has been developed in collaboration with physiotherapists ...
Health system-scale language models are all-purpose prediction engines.
Nature
Jun 7, 2023
Physicians make critical time-constrained decisions every day. Clinical predictive models can help physicians and administrators make decisions by forecasting clinical and operational events. Existing structured data-based clinical predictive models ...
Machine Learning in Clinical Trials: A Primer with Applications to Neurology.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
May 30, 2023
We reviewed foundational concepts in artificial intelligence (AI) and machine learning (ML) and discussed ways in which these methodologies may be employed to enhance progress in clinical trials and research, with particular attention to applications...
Multiscale deep learning framework captures systemic immune features in lymph nodes predictive of triple negative breast cancer outcome in large-scale studies.
The Journal of pathology
May 25, 2023
The suggestion that the systemic immune response in lymph nodes (LNs) conveys prognostic value for triple-negative breast cancer (TNBC) patients has not previously been investigated in large cohorts. We used a deep learning (DL) framework to quantify...
Assessment of Natural Language Processing of Electronic Health Records to Measure Goals-of-Care Discussions as a Clinical Trial Outcome.
JAMA network open
Mar 1, 2023
IMPORTANCE: Many clinical trial outcomes are documented in free-text electronic health records (EHRs), making manual data collection costly and infeasible at scale. Natural language processing (NLP) is a promising approach for measuring such outcomes...
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