BACKGROUND: Craniofacial phenotyping is essential for individualized orthodontic diagnosis and treatment planning. Traditional skeletal classifications, such as the ANB angle, may oversimplify complex relationships among malocclusion types. Machine l...
The combination of chemotherapy can enhance the efficacy of immune checkpoint inhibitors (ICIs), but requires precise patient stratification and biomarker screening. Cytokines influence immunotherapy outcomes, and multiplex cytokine profiling aids in...
Identifying novel and functional RNA structures remains a significant challenge in RNA motif design and is crucial for developing RNA-based therapeutics. Here we introduce a computational topology-based approach with unsupervised machine-learning alg...
OBJECTIVES: To identify and characterise distinct subgroups of patients with asthma with severe acute exacerbations (AEs) by using a multistep clustering methodology that combines supervised and unsupervised machine learning.
Environmental monitoring and assessment
Jul 4, 2025
The identification of aquatic macroinvertebrates, particularly dark taxa like Chironomidae, due to their complex morphological features and unresolved taxonomy hinder the efficiency of routine biomonitoring. This study proposes an unsupervised deep c...
In drug discovery, different data modalities (chemical structure, cell biology, quantum mechanics, etc.) are abundant, and their integration can help with understanding aspects of chemistry, biology, and their interactions. Within cell biology, cell ...
Various diseases including laminopathies and certain types of cancer are associated with abnormal nuclear mechanical properties that influence cellular and nuclear deformations in complex environments. Recently, microgroove substrates designed to mim...
Recognizing the level of driver distraction during the execution of secondary tasks within the intelligent cockpit is crucial for ensuring a seamless interaction between human drivers and intelligent vehicle systems. To address this issue, this paper...
Computer methods and programs in biomedicine
Jun 23, 2025
BACKGROUND AND OBJECTIVE: Population-scale hemodynamic research faces limitations due to the trade-off between computationally expensive patient-specific Computational Fluid Dynamics (CFD) and overly idealized cylindrical models. To overcome this, we...
BACKGROUND: Plastic-containing medical devices are commonly used in critical care units and other patient care settings. Patients are often exposed to xenobiotic agents that are leached out from plastic-containing medical devices, including bisphenol...
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