While convolutional neural network (CNN) has been demonstrating powerful ability to learn hierarchical spatial features from medical images, it is still difficult to apply it directly to resting-state functional MRI (rs-fMRI) and the derived brain fu...
In recent studies, neuroanatomical volume and shape asymmetries have been seen during the course of Alzheimer's Disease (AD) and could potentially be used as preclinical imaging biomarkers for the prediction of Mild Cognitive Impairment (MCI) and AD ...
Previous lesion behavior studies primarily used univariate lesion behavior mapping techniques to map the anatomical basis of spatial neglect after right brain damage. These studies led to inconsistent results and lively controversies. Given these inc...
Alzheimer's disease and related dementias (ADRD) are highly prevalent conditions, and prior efforts to develop predictive models have relied on demographic and clinical risk factors using traditional logistical regression methods. We hypothesized tha...
Combining machine learning with neuroimaging data has a great potential for early diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease (AD). However, it remains unclear how well the classifiers built on one population can predict MCI/...
Dementia and geriatric cognitive disorders
Jun 27, 2019
BACKGROUND: Socially assistive robots (SARs) have the potential to assist nonpharmacological interventions based on verbal communication to support the care of persons with dementia (PwDs). However, establishing verbal communication with a PwD is cha...
IEEE journal of biomedical and health informatics
Jun 17, 2019
Many classical machine learning techniques have been used to explore Alzheimer's disease (AD), evolving from image decomposition techniques such as principal component analysis toward higher complexity, non-linear decomposition algorithms. With the a...
Schizophrenia (SCZ) patients and their unaffected first-degree relatives (FDRs) share similar functional neuroanatomy. However, it remains largely unknown to what extent unaffected FDRs with functional neuroanatomy patterns similar to patients can be...
BACKGROUND: Hippocampus is one of the first structures affected by neurodegenerative diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). Hippocampal atrophy can be evaluated in terms of hippocampal volumes and shapes using ...
BACKGROUND: Recent deep learning models have shown remarkable accuracy for the diagnostic classification. However, they have limitations in clinical application due to the gap between the training cohorts and real-world data. We aimed to develop a mo...