Data-driven approaches have advanced colorectal lesion diagnosis in digestive endoscopy, yet their application in endocytoscopy (EC)-a high-magnification imaging technique-remains limited, with most studies relying on conventional machine learning me...
BACKGROUND: Lymph node metastasis (LNM) is a key prognostic factor in colorectal cancer (CRC), and early lymph node status assessment is crucial for prognosis and immunotherapy decisions. However, the immune characteristics of LNM-negative CRC remain...
Colorectal cancer (CRC) remains a major global health burden with high mortality rates, underscoring the need for effective therapies. This study explores the acetylation characteristics in CRC using single-cell RNA sequencing (scRNA-seq) and weighte...
This study compares various preprocessing techniques for hyperspectral deep learning-based cancer diagnostics. The study considers different spectrum scaling and noise reduction options across spatial and spectral axes of hyperspectral datacubes, as ...
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, mainly due to aberrant Wnt/β-catenin signaling resulting from APC mutations. Tankyrase is a key regulator of this pathway and plays a crucial role in stabilizing AXIN,...
UNLABELLED: Carcinoembryonic antigen (CEA) is a critical colorectal cancer (CRC) biomarker, but its mechanistic link to gut microbiota remains unclear. This study characterized gut microbiota differences between high-CEA (H-CEA) and low-CEA (L-CEA) C...
European journal of cancer (Oxford, England : 1990)
Sep 12, 2025
BACKGROUND AND AIMS: Current screening strategies for colorectal cancer (CRC) rely on colonoscopy, an invasive procedure with limited capacity to address individual risk. There is growing interest in integrating noninvasive immune biomarkers to impro...
Colorectal cancer (CRC) is a major global health challenge due to its high incidence, mortality, and low rate of early detection. Early diagnosis, targeting precancerous lesions (advanced adenomas) and early stage CRC (Tis and T1), is critical for im...
OBJECTIVES: Small animal models, particularly mice, are crucial for studying gastrointestinal diseases like colorectal cancer. Tumor assessment via colonoscopy generates large video datasets, necessitating automated analysis due to limited resources ...
Medical oncology (Northwood, London, England)
Aug 30, 2025
As one of the most prevalent malignancies worldwide, colorectal cancer (CRC) exhibits a strong metabolic dependency on glycolysis, which fuels tumor expansion and shapes an immunosuppressive microenvironment. Despite its clinical significance, the re...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.