BACKGROUND: Detection of highly divergent or yet unknown viruses from metagenomics sequencing datasets is a major bioinformatics challenge. When human samples are sequenced, a large proportion of assembled contigs are classified as "unknown", as conv...
BACKGROUND: Data-driven methods that automatically learn relations between attributes from given data are a popular tool for building mathematical models in computational biology. Since measurements are prone to errors, approaches dealing with uncert...
IEEE journal of biomedical and health informatics
Sep 20, 2018
The identification of copy number variations (CNVs) helps the diagnosis of many diseases. One major hurdle in the path of CNVs discovery is that the boundaries of normal and aberrant regions cannot be distinguished from the raw data, since various ty...
Despite advances in bioinformatics, custom scripts remain a source of difficulty, slowing workflow development and hampering reproducibility. Here, we introduce Vectools, a command-line tool-suite to reduce reliance on custom scripts and improve repr...
Journal of bioinformatics and computational biology
Sep 19, 2018
Protein Function Prediction from Protein-Protein Interaction Network (PPIN) and physico-chemical features using the Gene Ontology (GO) classification are indeed very useful for assigning biological or biochemical functions to a protein. They also lea...
BACKGROUND: Quantitative traits or continuous outcomes related to complex diseases can provide more information and therefore more accurate analysis for identifying gene-gene and gene- environment interactions associated with complex diseases. Multif...
Journal of genetics and genomics = Yi chuan xue bao
Sep 13, 2018
Gene set enrichment (GSE) analyses play an important role in the interpretation of large-scale transcriptome datasets. Multiple GSE tools can be integrated into a single method as obtaining optimal results is challenging due to the plethora of GSE to...
Identification of cancer prognostic genes is important in that it can lead to accurate outcome prediction and better therapeutic trials for cancer patients. Many computational approaches have been proposed to achieve this goal; however, there is room...
Genetics in medicine : official journal of the American College of Medical Genetics
Sep 10, 2018
Recent dramatic advances in multiomics research coupled with exponentially increasing volume, complexity, and interdisciplinary nature of publications are making it challenging for scientists to stay up-to-date on the literature. Strategies to addres...
The consistent evolution of ontologies is a major challenge for systems using semantically enriched data, for example, for annotating, indexing, or reasoning. The biomedical domain is a typical example where ontologies, expressed with different forma...
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