AIMC Topic: Computer-Aided Design

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Negshell casting: 3D-printed structured and sacrificial cores for soft robot fabrication.

PloS one Jun 12, 2020
Soft robot fabrication by casting liquid elastomer often requires multiple steps of casting or skillful manual labor. We present a novel soft robotic fabrication technique: negshell casting (negative-space eggshell casting), that reduces the steps re...
Fingers Mechanical Phenomena Silicone Elastomers Equipment Design Biomimetics Elastomers Elasticity Hand Strength Humans Printing, Three-Dimensional Computer-Aided Design Robotics
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Guided neural style transfer for shape stylization.

PloS one Jun 4, 2020
Designing logos, typefaces, and other decorated shapes can require professional skills. In this paper, we aim to produce new and unique decorated shapes by stylizing ordinary shapes with machine learning. Specifically, we combined parametric and non-...
Humans Machine Learning Computer-Aided Design Statistics, Nonparametric Computer Graphics Art Emblems and Insignia
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Revealing cytotoxic substructures in molecules using deep learning.

Journal of computer-aided molecular design Apr 16, 2020
In drug development, late stage toxicity issues of a compound are the main cause of failure in clinical trials. In silico methods are therefore of high importance to guide the early design process to reduce time, costs and animal testing. Technical a...
Software Computer-Aided Design Drug Design Cytotoxins Drug Discovery Deep Learning HEK293 Cells Humans Toxicology Neural Networks, Computer Hep G2 Cells Small Molecule Libraries Cell Survival Models, Biological
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Three-dimensional modelling of wheelchair contrived with lower limb exoskeleton for right hemiplegic dysfunction.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Apr 7, 2020
Hemiplegia is a type of paralysis that affects one side of the body due to stroke, characterizing severe weakness or rigid movement. Many people of different age groups are affected by this condition which cannot be completely cured but can be minimi...
Humans Biomechanical Phenomena Hemiplegia Exoskeleton Device Physical Therapy Modalities Wheelchairs Computer-Aided Design Imaging, Three-Dimensional Lower Extremity Robotics
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Big data and artificial intelligence discover novel drugs targeting proteins without 3D structure and overcome the undruggable targets.

Stroke and vascular neurology Mar 29, 2020
The discovery of targeted drugs heavily relies on three-dimensional (3D) structures of target proteins. When the 3D structure of a protein target is unknown, it is very difficult to design its corresponding targeted drugs. Although the 3D structures ...
Protein Conformation Proteins Databases, Protein Computer-Aided Design Structure-Activity Relationship Humans Pharmaceutical Preparations Drug Design Molecular Structure Artificial Intelligence Data Mining Drug Discovery Animals Ligands Big Data Molecular Targeted Therapy
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Bioinspired pursuit with a swimming robot using feedback control of an internal rotor.

Bioinspiration & biomimetics Mar 20, 2020
Theoretical guarantees of capture become complicated in the case of a swimming fish or fish robot because of the oscillatory nature of the fish heading. Building on the connection between a swimming fish and the canonical Chaplygin sleigh, a novel st...
Fishes Biomimetics Swimming Animals Computer-Aided Design Feedback Robotics Equipment Design
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Artificial intelligence in fixed implant prosthodontics: a retrospective study of 106 implant-supported monolithic zirconia crowns inserted in the posterior jaws of 90 patients.

BMC oral health Mar 19, 2020
BACKGROUND: Artificial intelligence (AI) is a branch of computer science concerned with building smart software or machines capable of performing tasks that typically require human intelligence. We present a protocol for the use of AI to fabricate im...
Dental Prosthesis, Implant-Supported Dental Implant-Abutment Design Adult Male Artificial Intelligence Middle Aged Titanium Retrospective Studies Computer-Aided Design Zirconium Female Humans Prosthodontics Aged Crowns
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CFD-based multi-objective controller optimization for soft robotic fish with muscle-like actuation.

Bioinspiration & biomimetics Mar 5, 2020
Soft robots take advantage of rich nonlinear dynamics and large degrees of freedom to perform actions often by novel means beyond the capability of conventional rigid robots. Nevertheless, there are considerable challenges in analysis, design, and op...
Swimming Hydrodynamics Equipment Design Fishes Biomimetics Feedback Animals Computer-Aided Design Muscle, Skeletal Robotics
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A Deep Learning Framework for Design and Analysis of Surgical Bioprosthetic Heart Valves.

Scientific reports Dec 6, 2019
Bioprosthetic heart valves (BHVs) are commonly used as heart valve replacements but they are prone to fatigue failure; estimating their remaining life directly from medical images is difficult. Analyzing the valve performance can provide better guida...
Image Processing, Computer-Assisted Prosthesis Design Feasibility Studies Heart Valve Prosthesis Implantation Biomechanical Phenomena Bioprosthesis Heart Valve Prosthesis Humans Computer-Aided Design Heart Valves Decision Support Techniques Finite Element Analysis Deep Learning Tomography, X-Ray Computed Models, Cardiovascular Prosthesis Failure
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Exploring fragment-based target-specific ranking protocol with machine learning on cathepsin S.

Journal of computer-aided molecular design Nov 15, 2019
Cathepsin S (CatS), a member of cysteine cathepsin proteases, has been well studied due to its significant role in many pathological processes, including arthritis, cancer and cardiovascular diseases. CatS inhibitors have been included in D3R-GC3 for...
Crystallography, X-Ray Protein Conformation Binding Sites Thermodynamics Computer-Aided Design Cathepsins Humans Protein Binding Machine Learning Databases, Protein Molecular Docking Simulation Ligands
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