AIMC Topic: Connectome

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Macroscale and microcircuit dissociation of focal and generalized human epilepsies.

Communications biology May 18, 2020
Thalamo-cortical pathology plays key roles in both generalized and focal epilepsies, but there is little work directly comparing these syndromes at the level of whole-brain mechanisms. Using multimodal imaging, connectomics, and computational simulat...
Epilepsy, Generalized Multimodal Imaging Female Connectome Young Adult Epilepsies, Partial Humans Adult Neural Networks, Computer Male Case-Control Studies Middle Aged Adolescent
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Interpretable Learning Approaches in Resting-State Functional Connectivity Analysis: The Case of Autism Spectrum Disorder.

Computational and mathematical methods in medicine May 18, 2020
Deep neural networks have recently been applied to the study of brain disorders such as autism spectrum disorder (ASD) with great success. However, the internal logics of these networks are difficult to interpret, especially with regard to how specif...
Functional Neuroimaging Computational Biology Support Vector Machine Autism Spectrum Disorder Humans Connectome Neural Networks, Computer Case-Control Studies Databases, Factual Magnetic Resonance Imaging Deep Learning Linear Models
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Grab-AD: Generalizability and reproducibility of altered brain activity and diagnostic classification in Alzheimer's Disease.

Human brain mapping May 4, 2020
Alzheimer's disease (AD) is associated with disruptions in brain activity and networks. However, there is substantial inconsistency among studies that have investigated functional brain alterations in AD; such contradictions have hindered efforts to ...
Connectome Basal Ganglia Default Mode Network Alzheimer Disease Datasets as Topic Cerebral Cortex Humans Machine Learning Magnetic Resonance Imaging Amyloid beta-Peptides Databases, Factual Cognitive Dysfunction
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The NanoZoomer artificial intelligence connectomics pipeline for tracer injection studies of the marmoset brain.

Brain structure & function May 4, 2020
We describe our connectomics pipeline for processing anterograde tracer injection data for the brain of the common marmoset (Callithrix jacchus). Brain sections were imaged using a batch slide scanner (NanoZoomer 2.0-HT) and we used artificial intell...
Artificial Intelligence Brain Animals Neural Pathways Atlases as Topic Callithrix Neuroanatomical Tract-Tracing Techniques Magnetic Resonance Imaging Neurons Connectome
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Ensemble Deep Learning on Large, Mixed-Site fMRI Datasets in Autism and Other Tasks.

International journal of neural systems Apr 18, 2020
Deep learning models for MRI classification face two recurring problems: they are typically limited by low sample size, and are abstracted by their own complexity (the "black box problem"). In this paper, we train a convolutional neural network (CNN)...
Nerve Net Big Data Magnetic Resonance Imaging Connectome Brain Cross-Sectional Studies Deep Learning Humans Autism Spectrum Disorder
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Discriminating stress from rest based on resting-state connectivity of the human brain: A supervised machine learning study.

Human brain mapping Apr 15, 2020
Acute stress induces large-scale neural reorganization with relevance to stress-related psychopathology. Here, we applied a novel supervised machine learning method, combining the strengths of a priori theoretical insights with a data-driven approach...
Humans Stress, Psychological Magnetic Resonance Imaging Supervised Machine Learning Connectome Female Adult Male Gyrus Cinguli Nerve Net Amygdala Parietal Lobe Default Mode Network
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Alzheimer's disease, mild cognitive impairment, and normal aging distinguished by multi-modal parcellation and machine learning.

Scientific reports Mar 25, 2020
A 360-area surface-based cortical parcellation is extended to study mild cognitive impairment (MCI) and Alzheimer's disease (AD) from healthy control (HC) using the joint human connectome project multi-modal parcellation (JHCPMMP) proposed by us. We ...
Aged, 80 and over Male Middle Aged Cognitive Dysfunction Machine Learning Magnetic Resonance Imaging Humans Cerebral Cortex Healthy Aging Diagnosis, Differential Female Connectome Alzheimer Disease Aged
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Bootstrapping promotes the RSFC-behavior associations: An application of individual cognitive traits prediction.

Human brain mapping Mar 16, 2020
Resting-state functional connectivity (RSFC) records enormous functional interaction information between any pair of brain nodes, which enriches the individual-phenotypic prediction. To reduce high-dimensional features, correlation analysis is a comm...
Support Vector Machine Brain Magnetic Resonance Imaging Image Processing, Computer-Assisted Connectome Humans Cognition
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Connectome-Based Propagation Model in Amyotrophic Lateral Sclerosis.

Annals of neurology Mar 11, 2020
OBJECTIVE: Clinical trials in amyotrophic lateral sclerosis (ALS) continue to rely on survival or functional scales as endpoints, despite the emergence of quantitative biomarkers. Neuroimaging-based biomarkers in ALS have been shown to detect ALS-ass...
Female Aged Male Deep Learning Amyotrophic Lateral Sclerosis Magnetic Resonance Imaging Middle Aged Humans Neuroimaging Disease Progression Connectome
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Hierarchical Organization of Functional Brain Networks Revealed by Hybrid Spatiotemporal Deep Learning.

Brain connectivity Mar 5, 2020
Hierarchical organization of brain function has been an established concept in the neuroscience field for a long time, however, it has been rarely demonstrated how such hierarchical macroscale functional networks are actually organized in the human b...
Deep Learning Magnetic Resonance Imaging Emotions Connectome Neural Pathways Humans Language Brain Spatio-Temporal Analysis
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