Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial i...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Dec 4, 2024
The coronavirus disease 2019 pandemic has underscored the importance of vaccines, especially for immunocompromised populations like solid organ transplant recipients, who often have weaker immune responses. The purpose of this study was to compare de...
OBJECTIVE: This study aimed to outline a machine learning model to assess the effectiveness of vaccination in COVID-19 confirmed cases and fatalities. The proposed model was evaluated using external validation to ensure optimal protection of vaccinat...
Pandemics like COVID-19 have a huge impact on human society and the global economy. Vaccines are effective in the fight against these pandemics but often in limited supplies, particularly in the early stages. Thus, it is imperative to distribute such...
In this study, we introduce a novel approach that integrates interpretability techniques from both traditional machine learning (ML) and deep neural networks (DNN) to quantify feature importance using global and local interpretation methods. Our meth...
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved T-cell epitopes is critical for designing effective vaccines. He...
Understanding which viral variants evade neutralization is crucial for improving antibody-based treatments, especially with rapidly evolving viruses like SARS-CoV-2. Yet, conventional assays are labor intensive and cannot capture the full spectrum of...
The bi-annual international congress on autoimmunity is a huge opportunity for the medical community to discuss the latest updates in the field. During the 14th congress 2024 (AUTO14) in Ljubljana, artificial intelligence (AI) occupied special attent...
Journal of epidemiology and global health
Nov 11, 2024
BACKGROUND: COVID-19 vaccination has become a pivotal global strategy in managing the pandemic. Despite COVID-19 no longer being classified as a Public Health Emergency of International Concern, the virus continues affecting people worldwide. This st...
International journal of biological macromolecules
Oct 18, 2024
The COVID-19 pandemic has underscored the critical importance of effective vaccines, yet their development is a challenging and demanding process. It requires identifying antigens that elicit protective immunity, selecting adjuvants that enhance immu...
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