Uremia is a serious complication of end-stage chronic kidney disease, closely associated with immune imbalance and chronic inflammation. However, its molecular mechanisms remain largely unclear. In this study, we analyzed transcriptomic data from the...
BACKGROUND: Breast cancer metastasis (BCM) metastasizes preferentially to certain organs. Important genetic markers can be used for early detection and treatment. Machine learning (ML) can efficiently handle gene expression data to enhance metastasis...
This study aims to explore the association between anoikis-related genes (ARGs) and asthma. The dataset GSE143303 for asthma were sourced from the GEO database, while ARGs were retrieved from the Harmonizome web portal and the GeneCards database. Dif...
Spinal cord injury (SCI) is a severe neurological disorder, with glucocorticoids like methylprednisolone commonly used for treatment. However, their efficacy and risks remain controversial. Programmed cell death (PCD) mechanisms have been increasingl...
Lung adenocarcinoma (LUAD) is a major challenge in oncology due to its complex molecular structure and generally poor prognosis. The aim of this study was to find diagnostic markers and therapeutic targets for LUAD by integrating differential gene ex...
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...
Diabetes is a complex metabolic disorder, and its pathogenesis involves the interplay of genetic, environmental factors, and lifestyle choices. With the rising prevalence and increasing associated chronic complications, identifying and understanding ...
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...
Early detection of lung nodules (LNs) is critical for prevention and treatment of lung cancer. However, current noninvasive diagnostic methods face significant challenges in reliably distinguishing benign from malignant nodules. Thus, there is an urg...
Renal stones (RS) are common urologic condition with unclear pathogenesis. Role of aging-related differentially expressed genes (ARDEGs) in RS remains poorly understood. This study aims to identify potential aging-related biomarkers for RS, explore t...
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