AIMC Topic: Databases, Nucleic Acid
Clear Filters Showing 31 to 40 of 88 articles
Screening and Bioinformatics Analysis of IgA Nephropathy Gene Based on GEO Databases.
BioMed research international
Jul 16, 2019
PURPOSE: To identify novel biomarkers of IgA nephropathy (IgAN) through bioinformatics analysis and elucidate the possible molecular mechanism.
Detection of DNA base modifications by deep recurrent neural network on Oxford Nanopore sequencing data.
Nature communications
Jun 4, 2019
DNA base modifications, such as C5-methylcytosine (5mC) and N6-methyldeoxyadenosine (6mA), are important types of epigenetic regulations. Short-read bisulfite sequencing and long-read PacBio sequencing have inherent limitations to detect DNA modifica...
Attention-Based Multi-NMF Deep Neural Network with Multimodality Data for Breast Cancer Prognosis Model.
BioMed research international
May 13, 2019
Today, it has become a hot issue in cancer research to make precise prognostic prediction for breast cancer patients, which can not only effectively avoid overtreatment and medical resources waste, but also provide scientific basis to help medical st...
Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder.
PLoS computational biology
Apr 11, 2019
Gestational alcohol exposure causes fetal alcohol spectrum disorder (FASD) and is a prominent cause of neurodevelopmental disability. Whole transcriptome sequencing (RNA-Seq) offer insights into mechanisms underlying FASD, but gene-level analysis pro...
CaseSolver: An investigative open source expert system based on EuroForMix.
Forensic science international. Genetics
Apr 2, 2019
For very serious crimes, reporting scientists often have to contend with complex cases where literally hundreds of items are submitted by investigators for analysis. In order to efficiently expedite the challenge of comparing reference profiles to ev...
Using Machine Learning to Measure Relatedness Between Genes: A Multi-Features Model.
Scientific reports
Mar 12, 2019
Measuring conditional relatedness between a pair of genes is a fundamental technique and still a significant challenge in computational biology. Such relatedness can be assessed by gene expression similarities while suffering high false discovery rat...
miRBaseConverter: an R/Bioconductor package for converting and retrieving miRNA name, accession, sequence and family information in different versions of miRBase.
BMC bioinformatics
Dec 31, 2018
BACKGROUND: miRBase is the primary repository for published miRNA sequence and annotation data, and serves as the "go-to" place for miRNA research. However, the definition and annotation of miRNAs have been changed significantly across different vers...
SFPEL-LPI: Sequence-based feature projection ensemble learning for predicting LncRNA-protein interactions.
PLoS computational biology
Dec 11, 2018
LncRNA-protein interactions play important roles in post-transcriptional gene regulation, poly-adenylation, splicing and translation. Identification of lncRNA-protein interactions helps to understand lncRNA-related activities. Existing computational ...
MSIpred: a python package for tumor microsatellite instability classification from tumor mutation annotation data using a support vector machine.
Scientific reports
Dec 3, 2018
Microsatellite instability (MSI) is characterized by high degree of polymorphism in microsatellite lengths due to deficiency in mismatch repair (MMR) system. MSI is associated with several tumor types and its status can be considered as an important ...
Prediction of plant-derived xenomiRs from plant miRNA sequences using random forest and one-dimensional convolutional neural network models.
BMC genomics
Nov 26, 2018
BACKGROUND: An increasing number of studies reported that exogenous miRNAs (xenomiRs) can be detected in animal bodies, however, some others reported negative results. Some attributed this divergence to the selective absorption of plant-derived xenom...
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