The extent to which genetic interactions affect observed phenotypes is generally unknown because current interaction detection approaches only consider simple interactions between top SNPs of genes. We introduce an open-source framework for increasin...
The retrieval of hit/lead compounds with novel scaffolds during early drug development is an important but challenging task. Various generative models have been proposed to create drug-like molecules. However, the capacity of these generative models ...
RATIONALE AND OBJECTIVES: Accurate identification of axillary lymph node (ALN) status in breast cancer patients is important for determining treatment options and avoiding axillary overtreatments. Our study aims to comprehensively compare the perform...
PURPOSE: A supervised deep learning (DL) approach for frequency and phase correction (FPC) of MRS data recently showed encouraging results, but obtaining transients with labels for supervised learning is challenging. This work investigates the feasib...
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Nov 11, 2022
PURPOSE: To (1) develop a deep-learning (DL) algorithm capable of producing limb-length and knee-alignment measurements, and (2) determine the association between limb-length discrepancy (LLD), coronal-plane alignment, osteoarthritis (OA) severity, a...
Intraoperative guidance tools for thyroid surgery based on optical coherence tomography (OCT) could aid distinguish between normal and diseased tissue. However, OCT images are difficult to interpret, thus, real-time automatic analysis could support t...
We have recently shown that histological phenotypes focusing on clear and eosinophilic cytoplasm in clear cell renal cell carcinoma (ccRCC) correlated with prognosis and the response to angiogenesis inhibition and checkpoint blockade. This study aims...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Nov 11, 2022
Although biopsy-based necrosis rate is a golden standard for reflecting the sensitivity of bone tumor and guiding postoperative chemotherapy, it requires biopsy which is invasive and time-consuming. In this paper, we develop a new necrosis rate detec...
PURPOSE: Extracting water equivalent diameter (DW), as a good descriptor of patient size, from the CT localizer before the spiral scan not only minimizes truncation errors due to the limited scan field-of-view but also enables prior size-specific dos...
BACKGROUND AND OBJECTIVE: In clinical practice, injectable drug combination (IDC) usually provides good therapeutic effects for patients. Numerous clinical studies have directly indicated that inappropriate IDC generates adverse drug events (ADEs). T...
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