AIMC Topic: Drug Delivery Systems

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Precise Control of Customized Macrophage Cell Robot for Targeted Therapy of Solid Tumors with Minimal Invasion.

Small (Weinheim an der Bergstrasse, Germany)
Injecting micro/nanorobots into the body to kill tumors is one of the ultimate ambitions for medical nanotechnology. However, injecting current micro/nanorobots based on 3D-printed biocompatible materials directly into blood vessels for targeted ther...

Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome.

Scientific reports
Delivery mode and perinatal antibiotics influence gut microbiome composition in children. Most microbiome studies have used the sequencing of the bacterial 16S marker gene but have not reported the metabolic function of the gut microbiome, which may ...

Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases.

Advanced drug delivery reviews
In the era of antimicrobial resistance, the prevalence of multidrug-resistant microorganisms that resist conventional antibiotic treatment has steadily increased. Thus, it is now unquestionable that infectious diseases are significant global burdens ...

Machine learning predicts 3D printing performance of over 900 drug delivery systems.

Journal of controlled release : official journal of the Controlled Release Society
Three-dimensional printing (3DP) is a transformative technology that is advancing pharmaceutical research by producing personalized drug products. However, advances made via 3DP have been slow due to the lengthy trial-and-error approach in optimizati...

Disrupting 3D printing of medicines with machine learning.

Trends in pharmacological sciences
3D printing (3DP) is a progressive technology capable of transforming pharmaceutical development. However, despite its promising advantages, its transition into clinical settings remains slow. To make the vital leap to mainstream clinical practice an...

Drug repurposing: Iron in the fire for older drugs.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Repositioning or "repurposing" of existing therapies for indications of alternative disease is an attractive approach that can generate lower costs and require a shorter approval time than developing a de novo drug. The development of experimental dr...

Machine learning directed drug formulation development.

Advanced drug delivery reviews
Machine learning (ML) has enabled ground-breaking advances in the healthcare and pharmaceutical sectors, from improvements in cancer diagnosis, to the identification of novel drugs and drug targets as well as protein structure prediction. Drug formul...

Robotics for enzyme technology: innovations and technological perspectives.

Applied microbiology and biotechnology
The use of robotics in the life science sector has created a considerable and significant impact on a wide range of research areas, including enzyme technology due to their immense applications in enzyme and microbial engineering as an indispensable ...

Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability.

ACS applied materials & interfaces
Therapeutic drug delivery microrobots capable of accurate targeting using an electromagnetic actuation (EMA) system are being developed. However, these drug delivery microrobots include a large number of magnetic nanoparticles (MNPs) for accurate EMA...

Machine learning to determine optimal conditions for controlling the size of elastin-based particles.

Scientific reports
This paper evaluates the aggregation behavior of a potential drug and gene delivery system that combines branched polyethyleneimine (PEI), a positively-charged polyelectrolyte, and elastin-like polypeptide (ELP), a recombinant polymer that exhibits l...